Abstract
Beta-phenylethylamine (PE) (75 mg/kg once daily) was administered to mice for 1, 4 or 9 days, and behavioural and biochemical experiments performed 1 day after the last treatment dose. There was no quantitative change in sensitivity of PE treated mice to the post synaptic dopamine (DA) receptor stimulant effects of apomorphine, nor was there any change in striatal [3H]-spiperone binding after 4 or 9 days of PE treatment. After 9 days of treatment (but not after 4) there was a marked trend for PE treated animals to be subsensitive to the locomotor depressant effects of low doses of apomorphine. The effect of PE treatment on the stimulant effects of amphetamine was complex, with both subsensitive and supersensitive components being evident. This was dependent upon duration of treatment and habituation to the environment. PE treatment did not affect tyrosine hydroxylase activity in the striatum (as assessed by DOPA accumulation after inhibition of DOPA decarboxylase) and did not affect the rate of striatal DA disappearance after tyrosine hydroxylase inhibition.
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References
Antelman S.M., Edwards D.J., and Lin M. (1977) Phenylethylamine: evidence for a direct postsynaptic dopamine-receptor stimulating action. Brain Research 127, 317–322.
Atack C.V. (1973) The determination of dopamine by a modification of the dihydroxyindole fluorimetric assay. Br. J. Pharmacol. 48, 699–714.
Atack C.V., and Magnusson T. (1978) A procedure for the isolation of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine from the same tissue sample using a single column of strongly acidic cation exchange resin. Acta Pharmacol. Toxicol. (Copenh). 42, 35–57.
Bailey R.C. and Jackson D.M. (1978) A pharmacological study of changes in central nervous system receptor responsiveness after long-term dexamphetamine and apomorphine administration. Psychopharmacol. 56, 317–326.
Braestrup C., and Randrup A. (1978) Stereotyped behaviour in rats induced by phenylethylamine, dependence on dopamine and noradrenaline, and possible relation to psychosis?, in Noncatecholic Phenylethylamines, Part I. Phenylethylamine: Biological Mechanisms and Clinical Aspects (Mosnaim A. and Wolf M.E., eds), pp. 245–269. Marcel Dekker Inc., New York.
Carlsson A. (1975) Receptor-mediated control of dopamine metabolism, in Pre- and Postsynaptic Receptors (Usdin E., and Bunney W.E., eds), Marcel Dekker Inc., New York.
Carlsson A.K., Fuxe K., Hamberger B., and Lindqvist M. (1966) Biochemical and histochemical studies on the effects of imipramine like drugs and amphetamine on central and peripheral catecholamine neurons. Acta Physiol. Scand. 67, 481–497.
Dourish C.T. (1982) An observational analysis of the behavioural effects of beta-phenylethylamine in isolated and grouped mice. Prog. Neuropsychopharmacol. Biol. Psychiat., 6, 143.
Fuxe K., Grobecker H., and Jonsson J. (1967) The effect of beta-phenylethylamine on central and peripheral monoamine-containing neurons. Europ. J. Pharmacol. 2, 202–207.
Hjorth S., Carlsson A., Lindberg P., Sanchez D., Wiksrom H., Arvidsson L.E., Hacksell U., Nilsson J.L.G., and Svensson U. (1980) A new centrally acting DA receptor agonist with selectivity for autoreceptors. Psychopharmacol. Bull. 16, 85–90.
Jackson D.M. (1972) The effect of beta-phenethylamine upon spontaneous motor activity in mice: a dual effect on locomotor activity. J. Pharm. Pharmacol. 24, 383–389.
Jackson D.M. (1975a) Beta-phenylethylamine and locomotor activity in mice. Interaction with catecholaminergic neurones and receptors. Arzneimittel-Forschung 25, 622–626.
Jackson D.M., Bailey R.C., Christie M.J., Crisp E.A., and Skerritt J.H. (1981) Long-term d-amphetamine in rats: lack of change in post-synaptic dopamine receptor sensitivity. Psychopharmacol. 73, 276–280.
Jackson D.M., Carlsson A., Hjorth S., and Lindberg P. (1982a) A behavioural study of the changes in the central nervous system of mice after subchronic treatment with the selective dopamine autoreceptor agonist 3-PPP (d1-3-[3 hydroxyphenyl]-N-n- propylpiperidine). J. Neural Transm. 53, 233–245.
Jackson D.M., Walters J.R., and Miller L.P. (1982b) Chronic L-DOPA-pretreatment of rats: an electrophysiological and biochemical study in the basal ganglia. Brain Research 250, 271–182.
Karoum F., Speciale S.G., Chuang L-W., and Wyatt R.J. (1982) Selective effects of phenylethylamine on central catecholamines: a comparative study with amphetamine. J. Pharmacol. Exp. Ther., 223, 432–439.
Kehr W., Carlsson A., and Lindqvist M. (1972) A method for the determination of 3,4-dihydroxyphenylalanine (D0PA) in brain. Naunyn-Schmiedeberg’s Arch. Pharmacol. 274, 273–280.
Lowry O.K., Rosebrough N.J., Farr A.L., and Randall R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265–275.
Mantegazza P., and Riva M. (1963) Amphetamine-like activity of beta-phenylethylamine after a monoamine oxidase inhibitor in vivo. J. Pharm. Pharmacol. 15, 472–478.
Muller P., and Seeman P. (1979) Presynaptic subsensitivity as a possible basis for sensitisation by long-term dopamine mimetics. Europ. J. Pharmacol. 55, 149–158 (1979).
Pycock C., Dawbarn D., and OO’Shaughnessy C. (1982) Behavioural and biochemical changes following chronic administration of L-DOPA to rats. Europ. J. Pharmacol. 79, 201–215.
Rebec G.V., and Segal D.S. (1979) Enhanced responsiveness to intraventricular infusion of amphetamine following its repeated systemic administration. Psychopharmacol. 62, 101–102.
Robertson H.A. (1982) Chronic phencyclidine, like amphetamine, produces a decrease in [3H]-spiroperidol binding in rat striatum. Europ. J. Pharmacol. 78, 363–365.
Sabelli H.C., Borison R.L., Diamond B.I., May J., and Havdala U.S. (1978) 2-Phenylethylamine as a neuromodulator of wakefulness, affect, and extrapyramidal function: recent advances, in Noncatecholic Phenylethylamines, Part I. Phenylethylamine: Biological Mechanisns and Clinical Aspects (Mosnaim A., and Wolfe M.E., eds), pp. 345–376. Marcel Dekker Inc., Hew York.
Strombom U. (1976) Catecholamine receptor agonists: effects on motor activity and rate of tyrosine hydroxylation in mouse brain. Naunyn-Schmiedeberg’s Arch. Pharmacol. 292, 167–176.
Wagner G.C., Ricaurte G.A., Seiden L.S., Schuster C.R., Miller R.J., and Westley J. (1980) Long-lasting depletions of striatal dopamine-uptake sites following repeated administration of methamphetamine. Brain Research 181, 151–160.
Winer B.J. (1971) Statistical Principles in Experimental Design. McGraw-Hill Kogakusha, Ltd., Tokyo.
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Jackson, D.M., Jenkins, O.F. (1984). Beta-Phenylethylamine: Some Preliminary Chronic Studies. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_30
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_30
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