Abstract
Direct tryptamine (T) effects in the rat brain and in rabbit aortic strips have been reported (Jones, 1982; Stollak and Furchgott, 1983); moreover, in the rat brain, there appear to be distinct T receptors (Kellar and Cascio, 1982; Cascio and Kellar, 1982). It is conceivable, then, that T may be a transmitter in the rat brain. If so, T should be accumulated by a high-affinity uptake system which is sodium-, temperature- and energy-dependent; in addition, depolarization induced release of T should be calcium-dependent (Iversen, 1974; Thoa et al., 1975). The following study was undertaken to determine whether T transport exhibited these characteristics.
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References
Born G.V.R., Juengjaosen K. and Michal F. (1972) Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues. Br. J. Pharmacol. 44, 117–139.
Boulton A.A. (1976) Identification, distribution, metabolism and function of meta- and para-tyramine, phenylethylamine and tryptamine in brain. Adv. Biochem. Psychopharmacol. 15, 57–67.
Cascio C.S. and Kellar K.J. (1982) Tetrahydro-ß-carbolines: affinities for tryptamine and serotonergic binding sites. Neuropharmacol. 21, 1219–1221.
Dyck L.E. (1978) Uptake and release of meta-tyramine, para-tyramine and dopamine in rat striatal slices. Neurochem. Res. 4, 633–642.
Hery F., Simonnet G., Bourgoin S., Soubrie P., Artaud F., Hamon M. and Glowinski J. (1979) Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from L-[3H]tryptophan in the caudate nucleus of the cat. Brain Res. 169, 317–334.
Hery M., Faudon M.V. and Hery F. (1983) Invitro release of newly synthesized serotonin from superfused rat suprachiasmatic area-ionic dependency. Eur. J. Pharmacol. 89, 9–18.
Iversen L.L. (1974) Uptake mechanisms for neurotransmitter amines. Biochem. Pharmacol. 23, 1927–1935.
Jones R.S.G. (1982) A comparison of the responses of cortical neurones to iontophoretically applied tryptamine and 5-HT in the rat. Neuropharmacol. 21, 209–214.
Jones R.S.G. and Broadbent J. (1982) Differential effects of fluoxetine and zimelidine on the uptake of 5-hydroxy-tryptamine and tryptamine by cortical slices and on responses of cortical neurones to stimulation of the nucleus raphé medianus. Eur. J. Pharmacol. 81, 681–685.
Kellar K.J. and Cascio C.S. (1982) [3H] Tryptamine: high affinity binding sites in rat brain. Eur. J. Pharmacol. 18, 475–478.
Osborne N.N. (1980) Specificity of serotonin uptake by bovine retina: comparison with tryptamine. Exp. Eye Res. 31, 31–39.
Ross S.B. and Ask A.L. (1980) Structural requirements for uptake into serotonergic neurones. Acta Pharmacol. Toxicol. 46, 270–277.
Schroder H.U., Neuhoff V., Priggemeier E. and Osborne N.N. (1979) The influx of tryptamine into snail (helix pomatia) ganglia: comparison with 5-hydroxytryptamine. Malacologia 18, 517–525.
Snodgrass S.R. and Iversen L.L. (1974) Formation and release of 3H-tryptamine from 3H-tryptophan in rat spinal cord slices. Adv. Biochem. Psychopharmacol. 10, 141–150.
Stacy R.S. (1961) Uptake of 5-hydroxytryptamine by platelets. Br. J. Pharmacol. 16, 284–295.
Stollak J.S. and Furchgott R.F. (1983) Use of selective antagonists for determining the types of receptors mediating the actions of 5-hydroxytryptamine and tryptamine in the isolated rabbit aorta. J. Pharmacol. Exp. Ther. 224, 215–221.
Thoa N.B., Wooten G.F., Axelrod J. and Kopin I.J. (1975) On the mechanism of release of noradrenaline from sympathetic nerves induced by depolarizing agents and sympathomimetic drugs. Mol. Pharmacol. 11, 10–18.
Wu P.H. and Boulton A.A. (1973) Distribution and metabolism of tryptamine in rat brain. Can. J. Biochem. 51, 1104–1112.
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Dyck, L.E. (1984). The Uptake and Release of 14C-Tryptamine by Rat Brain Slices. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_19
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_19
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