Abstract
The trace amines phenylethylamine (PE), p-tyramine (p-TA), m-tyramine (m-TA) and tryptamine (T) have been analyzed as their dansyl derivatives by the highly specific and sensitive integrated ion current mass spectrometric procedure. Of the rat tissues examined, the kidney contained the highest concentrations of the trace amines. In the brain, these substances were anatomically most concentrated in the caudate nucleus, while subcellularly, significant amounts were associated with particulate material, including the synaptosomes. PE and T, and to a lesser extent p-TA and m-TA, exhibited very high turnover rates and their tissue concentrations increased rapidly after inhibition of monoamine oxidase. The accumulation rates of PE and T in the brains of rats treated with pargyline were similar to those of the classical neurotransmitters dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT), although these latter compounds are present endogenously in much greater amounts. The trace amines have also been identified in various regions of the human brain and appear to be most concentrated in the basal ganglia.
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Philips, S.R. (1984). Analysis of Trace Amines: Endogenous Levels and the Effects of Various Drugs on Tissue Concentrations in the Rat. In: Boulton, A.A., Baker, G.B., Dewhurst, W.G., Sandler, M. (eds) Neurobiology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5312-9_12
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DOI: https://doi.org/10.1007/978-1-4612-5312-9_12
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