Skip to main content

Glycosyltransferases in Protein Glycosylation

  • Chapter
Protein Synthesis

Abstract

Glycosylation of glycoproteins in eucaryotic cells is initiated on nascent polypeptide chains in the endoplasmic reticulum and completed post-translationally in the lumen of the Golgi apparatus. Recent interest in the details of protein glycosylation stems from our presently incomplete knowledge of the structure, functions and mechanisms of biosynthesis of oligosaccharides in glycoproteins and other glycoconjugates.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aminoff, D., Gathmann, W.D. and Baig, M.M. (1979) J. Biol. Chem., 214, 8909-8913.

    Google Scholar 

  • Ashwell, G. and Harford, J. (1982) Annu. Rev. Biochem., 51, 531–554.

    Article  PubMed  CAS  Google Scholar 

  • Beyer, T.A., Rearick, J.I., Paulson, J.C., Prieels, J.-P., Sadler. J.E., and Hill, R.L. (1979) J. Biol. Chem. 254, 12531–12541.

    PubMed  CAS  Google Scholar 

  • Beyer, T.A., Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L. (1981) Adv. Enzymol., A. Meister, ed., 52, 23–175.

    Google Scholar 

  • Coates, S.W., Gurney, Jr., T., Sommers, L.W., Yeh, M. and Hirschberg, C.B. (1980) J. Biol. Chem. 255, 9225–9229.

    PubMed  CAS  Google Scholar 

  • Cummings, R.D., Trowbridge, I.S. and Kornfeld, S. (1982) J. Biol. Chem. 257, 13421–13427.

    PubMed  CAS  Google Scholar 

  • Das, R.C. and Heath, E.C. (1980) Proc. Natl. Acad. Sci., USA, 77, 3811–3815.

    Article  PubMed  CAS  Google Scholar 

  • Dunphy, W.G., Fries, E., Drbani, I.J. and Rothman, J.E. (1981) Proc. Natl. Acad. Sci., USA, 21, 7453–7457.

    Article  Google Scholar 

  • Farquhar, M.G. (1983) Federation Proc. 42, 2407–2413.

    CAS  Google Scholar 

  • Goldberg. D.E. and Kornfeld, S. (1983) J. Biol. Chem. 258, 3159–3164.

    PubMed  CAS  Google Scholar 

  • Hill, H.D., Reynolds, J.A., and Hill, R.L. (1977) J. Biol. Chem. 252, 3791–3798.

    PubMed  CAS  Google Scholar 

  • Hochman, Y. and Zakim, D. (1983) J. Biol. Chem. 258, 4143–4146.

    PubMed  CAS  Google Scholar 

  • Hubbard, S.C. and Ivatt, R.J. (1981) Annu. Rev. Biochem., 50, 555–583.

    Article  PubMed  CAS  Google Scholar 

  • Ivatt, R.J. (1981) Proc. Natl. Acad. Sc., USA, 28. 4021–4025.

    Article  Google Scholar 

  • Kuhn, N.J., Wooding, F.B.P. and White, A. (1980) Eur. J. Biochem., l03, 377–385.

    Article  Google Scholar 

  • Mendicino, J., Chandrasekaran, E.V., Anumula, K.R. and Davila, M. (1981) Biochemistry, 20, 957–976.

    Article  Google Scholar 

  • Mitranic, M.M. and Moscarello, M.A. (1980), Can. J. Biochem., 58, 809–814.

    Article  PubMed  CAS  Google Scholar 

  • Neufeld, E. and Ashwell, G. (1980) in ‘The Biochemistry of Glycoproteins and Proteoglycans’, W.J. Lennarz, ed., Plenum Press, New York, pp. 241–266.

    Google Scholar 

  • Oppenheimer, C.L., Eckhardt, A.E. and Hill, R.L. (1981) J. Biol. Chem. 256, 11477–11482.

    PubMed  CAS  Google Scholar 

  • Oppenheimer, C.L. and Hill, R.L. (1981) J. Biol. Chem. 256, 799–804.

    PubMed  CAS  Google Scholar 

  • Paulson, J.C., Rearick, J.I. and Hill, R.L. (1977) J. Biol. Chem. 252, 2363–2371.

    PubMed  CAS  Google Scholar 

  • Pearse, B.M.F. and Bretscher, M.S. (1981) Annu. Rev. Biochem. 50, 85–101.

    Article  PubMed  CAS  Google Scholar 

  • Prieels, J.-P., Monnom, D., Dolmans, M., Beyer, T.A., and Hill, R.L. (1981) J. Biol. Chem. 256, 10456–10463.

    PubMed  CAS  Google Scholar 

  • Reitman, M.L., and Kornfeld, S. (1981) J. Biol. Chem. 256, 4275–4281.

    PubMed  CAS  Google Scholar 

  • Rodén, L. (1980) in ‘The Biochemistry of Glycoprotein and Proteoglycans’, W.J. Lennarz, ed.. Plenum Press, New York, pp. 267–371.

    Google Scholar 

  • Roth, J. and Berger, E.G. (1982) J. Cell Biol. 92, 223–229.

    Article  Google Scholar 

  • Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L. (1979) J. Biol. Chem. 254, 4434–4443.

    PubMed  CAS  Google Scholar 

  • Sandcrman. Jr., H.(1978) Biochim. Biophys. Acta., 515. 209–237.

    Google Scholar 

  • Schwartz, N.B. and Roden, L. (1975) J. Biol. Chem., 250, 5200–5207.

    PubMed  CAS  Google Scholar 

  • Slomiany, A., Slomiany, B.L. (1978) J. Biol. Chem., 253, 7301–7306.

    PubMed  CAS  Google Scholar 

  • Sommers, L.W. and Hirschberg, C.B. (1982) J. Biol. Chem. 257, 10811–10817.

    PubMed  CAS  Google Scholar 

  • Spik, G., Bayard, B., Fournet, B., Strecker, G., Bouquelet, S., and Montreuil, J. (1975) FEBS Lett., 50, 296–299.

    PubMed  CAS  Google Scholar 

  • Strous, G.J.A.M. (1979) Proc. Natl. Acad. Sei., USA, 76, 2694–2698.

    Article  CAS  Google Scholar 

  • Tabas, I. and Kornfeld, S. (1978) J. Biol. Chem. 253, 7779–7786.

    PubMed  CAS  Google Scholar 

  • Thomas, D.B. and Winzler, R.J. (1969) J. Biol. Chem. 244, 5943–5946.

    PubMed  CAS  Google Scholar 

  • Varki, A. and Kornfeld, S. (1981) J. Biol. Chem. 216, 9937–9943.

    Google Scholar 

  • Weinstein, J., de Souza-e-Silva, D. and Paulson, J.C. (1982) J. Biol. Chem. 251, 13845–13853.

    Google Scholar 

  • Westcott, K.R. and Hill, R.L. (1982) Fed. Proc. 41, 662.

    Google Scholar 

  • Wilson, J.R., Williams, D. and Schachter, H. (1976) Biochen. Biophys. Res. Common., 72, 909–916.

    Article  CAS  Google Scholar 

  • Wolf, C., Westcott, K.R., and Hill R.L., unpublished observations.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1983 The Human Press Inc.

About this chapter

Cite this chapter

Nygård, O., Westermann, P. (1983). Glycosyltransferases in Protein Glycosylation. In: Abraham, A.K., Eikhom, T.S., Pryme, I.F. (eds) Protein Synthesis. Humana Press. https://doi.org/10.1007/978-1-4612-5310-5_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5310-5_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9780-2

  • Online ISBN: 978-1-4612-5310-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics