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On the Transport of Secretory Proteins From the Endoplasmic Reticulum to the Golgi Complex

  • Odd Nygård
  • Peter Westermann
Chapter
  • 62 Downloads

Abstract

Early in the evolution of the living cell there must have appeared proteins that spanned the plasma membrane and which mediated the uptake and disposal of specific molecules. Proteins of this kind, that were bound to the cell membrane and that were partially exposed to the exterior of the cell, might also have come to serve other functions, such as degrading macromolecules in the surrounding medium to forms that could be taken up and be used as nutrients by the cell. It is reasonable to assume that it would have been an advantage for those early cells to shed, or secrete, those degrading proteins, thereby making the processing of the nutrients in the medium more efficient (1).

Keywords

Endoplasmic Reticulum Secretory Protein Chinese Hamster Ovary Cell Golgi Complex Retinol Binding Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    de Duve and Wattiaux, R. (1966) Annu. Rev. Physiol. 28, 435PubMedCrossRefGoogle Scholar
  2. 2.
    Blobel, G. (1980) Proc. Natl. Acad. Sci. USA 77, 1496PubMedCrossRefGoogle Scholar
  3. 3.
    Sabatini,D.D., Kreibich,G., Morimoto,T., and Adesnik,M. (1982), 92,1Google Scholar
  4. 4.
    Palade,G.E. (1982) in Ciba Found. Syrap. 92, 1Google Scholar
  5. 5.
    Rothman, J.E. (1981), Science (Wash.DC) 213, 1212CrossRefGoogle Scholar
  6. 6.
    Tartakoff, A. (1981) Int. Rev. Exp. Pathol. 22, 227Google Scholar
  7. 7.
    Brown, M.S., Anderson, R.G.W. and Goldstein J.L. (1983), Cell 32, 663PubMedCrossRefGoogle Scholar
  8. 8.
    Pearse, B.M.F. and Bretscher (1981) Annu. Rev. Bioch. 50, 85CrossRefGoogle Scholar
  9. 9.
    Kreibich, G. Debey, P. and Sabatini, D.D. (1973), J.Cell Biol. 58, 436PubMedCrossRefGoogle Scholar
  10. 10.
    Palade, G.E. (1975) Science(WashDC) 189, 347CrossRefGoogle Scholar
  11. 11.
    Tartakoff, A.M., Jamieson, J., Scheele, G.A., and Palade, G.E. (1975) J. Biol. Chem. 250, 2671PubMedGoogle Scholar
  12. 12.
    Peters, T., Fleischer, B., and Flesicher, S. (1971) J. Biol. Chem. 246, 240PubMedGoogle Scholar
  13. 13.
    Morgan, E.H., and Peters, T., (1971) J. Biol. Chem. 246, 3508PubMedGoogle Scholar
  14. 14.
    Strous, G. and Lodish, H.F. (1980) Cell 22, 709PubMedCrossRefGoogle Scholar
  15. 15.
    Fries, E., Unger, E.,Gustafsson, L. and Peterson, P.E., submitted for publicationGoogle Scholar
  16. 16.
    Fitting, T. and Kabat, D. (1982) J. Biol. Chem. 257, 14011PubMedGoogle Scholar
  17. 17.
    Wu, G.E., Hozumi, N. and Murialdo, H. (1983) Cell 33, 77PubMedCrossRefGoogle Scholar
  18. 18.
    Jamieson, J.D. and Palade, G.E. (1967) J. CellBiol. 34, 577PubMedCrossRefGoogle Scholar
  19. 19.
    Yokota, S. and Fahimi, H.D. (1981)Proc. Natl. Acad. Sci. USA 78, 4970PubMedCrossRefGoogle Scholar
  20. 20.
    Rothman, J.E. and Fine, R.E. (1980) Proc. Natl. Acad. Sci. USA 77, 780PubMedCrossRefGoogle Scholar
  21. 21.
    Locke, M and Huie, P. (1976) J. Cell Biol. 7o, 384CrossRefGoogle Scholar
  22. 22.
    Croze, E.M., Morre, D.M., Kartenbeck, J., Franke, W. and Morre, D.J (1982) J. Cell. Biol. 95, 459aGoogle Scholar
  23. 23.
    Carlson, J. and Stenflo, J. (1982) J. Biol. Chem. 257, 12987PubMedGoogle Scholar
  24. 24.
    Lenard, J. (1978) Annu. Rev. Biophys. Bioeng. 7, 139PubMedCrossRefGoogle Scholar
  25. 25.
    Robbins, P., Hubbard, S. and Wirth, D. (1977) Cell 12, 893PubMedCrossRefGoogle Scholar
  26. 26.
    Gottlieb, C.,Baenzinger and Kornfeld, S. (1975) J. Biol. Chem. 250, 3303PubMedGoogle Scholar
  27. 27.
    Li, E, and Kornfeld (1978) J. Biol. Chem. 253,6426PubMedGoogle Scholar
  28. 28.
    Fries, E, and Rothman, J.E.(1981) J. CellBiol. 90, 697PubMedCrossRefGoogle Scholar
  29. 29.
    Dunphy, W.G., Fries, E., Urbani, L.J. and Rothman, J.E (1981) Proc. Natl. Acad. Sci. USA 78, 7453PubMedCrossRefGoogle Scholar
  30. 30.
    Rothman,J.E., Fries, E., Dunphy.W.G. and Urbani,L.J. (1982) Cold Spring Harbor Symposia on Quant.Biol. Vol.XLVI, 797Google Scholar

Copyright information

© The Human Press Inc. 1983

Authors and Affiliations

  • Odd Nygård
    • 1
  • Peter Westermann
    • 2
  1. 1.The Wenner-Gren InstituteUniversity of StockholmStockholmSweden
  2. 2.Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlin-BuchGermany

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