Advertisement

Intracellular Transport of Endocytosed Glycoproteins in Rat Hepatocytes

  • Odd Nygård
  • Peter Westermann
Chapter
  • 62 Downloads

Abstract

The mammalian liver consists of four main cell types: the parenchymal cells, the macrophages (Kupffer cells), the endothelial cells, and the stellate cells (1). Apart from the stellate cells all of these cell types are able to remove macromolecules from the blood by endocytosis. This function contributes to the homeostatic system which keeps the concentration of plasma proteins and lipids relatively constant. The various ligands endocytosed by the liver are to some extent divided between the cells. For instance, only hepatocytes take up chylomicron remnants or asialoglycoproteins (2). Endothelial cells are particularly active in the uptake of proteins with increased negative charge such as acetylated LDL (3) or formaldehydetreated albumin (4), while Kupffer cells are specialized phagocytic cells. The main function of the stellate cells seems to be storage of retinol received from the hepatocytes (5,6).

Keywords

Kupffer Cell Stellate Cell Sucrose Gradient Intracellular Transport Endocytic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Wisse, E., J. Ultrastructure Res. 46, 393 (1974)CrossRefGoogle Scholar
  2. 2.
    Norum, K.R., Berg, T., and Drevon, C.A., in L.A. Carlson and B. Pernow (Editors), Metabolic risk factors in ischemic caridiovascular disease, Raven Press, New York, 1982,p. 35.Google Scholar
  3. 3.
    Nagelkerke, J.F., Barto, K.P., and Van Berkel, T.J.C., in D.L. Knook and E. Wisse (Editors), Sinusoidal liver cells, Elsevier Biomedical Press, Amsterdam, 1982, p. 319.Google Scholar
  4. 4.
    Blomhoff, R., Eskild, W., and Berg, T. (1983) (submitted).Google Scholar
  5. 5.
    Blomhoff, R., Helgerud, P., Rasmussen, M., Berg, T., and Norum, K.R., Proc. Natl. Acad. Sci. (USA) 79, 7326 (1982).CrossRefGoogle Scholar
  6. 6.
    Berg, T., Blomhoff, R., and Norum, K.R., in D.L. Knook and E. Wisse (Editors),Sinusoidal liver cells,Elsevier Biomedical Press, Amsterdam, 1982, p. 37.Google Scholar
  7. 7.
    Tolleshaug, H., Berg, T., Nilsson, M., and Norum, K.R., Biochim. Biophys. Acta, 499, 73 (1977)PubMedCrossRefGoogle Scholar
  8. 8.
    Nilsson, A, and Akesson, B., FEBS-letters, 51, 219, (1975).PubMedCrossRefGoogle Scholar
  9. 9.
    Higa, Y., Oshiro, S., Kino, K., Tsuno, H., and Nakajima, H., J. Biol. Chem., 256, 12322 (1981).Google Scholar
  10. 10.
    Ose, L., Ose, t:, Reinertsen, R., and Berg, T, Exp. Cell Res., 126, 109 (1980).PubMedCrossRefGoogle Scholar
  11. 11.
    Tolleshaug, H., Int. J. Biochem., 13, 45 (1981).PubMedCrossRefGoogle Scholar
  12. 12.
    Blomhoff, R., Tolleshaug, H., and Berg, T., J. Biol. Chem. 257, 7456 (1982).PubMedGoogle Scholar
  13. 13.
    Tolleshaug, H., and Berg, T., Exp. Cell Res. 134, 207 (1981).PubMedCrossRefGoogle Scholar
  14. 14.
    Kolset, S.O., Tolleshaug, H., and Berg, T., Exp. Cell Res. 122, 159 (1979).PubMedCrossRefGoogle Scholar
  15. 15.
    Tartakoff, A.M., and Bassalli, P., J. Exp. Med. 146, 1332 (1977).PubMedCrossRefGoogle Scholar
  16. 16.
    Berg, T., Blomhoff, R., N£Ss, L., Tolleshaug, H., and Drevon, C.A., Exp. Cell Res. (In press)Google Scholar
  17. 17.
    Tolleshaug, H., Chindemi, P.A., and Regoeczi, E., J. Biol. Chem. 256, 6526 (1981).PubMedGoogle Scholar
  18. 18.
    Tycko, B., and Maxfield, F.R., Cell, 28, 643 (1982).Google Scholar
  19. 19.
    Geuze, H.J., Slot, J.W., Strous, G.J.A.M., Lodish, H.F., and Schwartz, A.L., Cell, 32, 277 (1983).PubMedCrossRefGoogle Scholar
  20. 20.
    Berg, T., and Tolleshaug, H., Biochem. Pharmacol., 29, 917 (1980).PubMedCrossRefGoogle Scholar
  21. 21.
    Ose, L., Ose, T., Norum, K.R., and Berg, T., Biochim. Biophys. Acta, 620, 120 (1980).PubMedGoogle Scholar
  22. 22.
    Hubbard, A.L., Wilson, G., Ashwell, G., and Stukenbrok, H., J. Cell Biol., 83, 47 (1979).PubMedCrossRefGoogle Scholar
  23. 23.
    Maynard, Y., and Baenziger, J.U., J. Biol. Chem. 257, 3788 (1982).PubMedGoogle Scholar
  24. 24.
    Mori, K., Kawasaki, T., and Yamashina, I., Arch. Biochem. Biophys. 222, 542 (1983).PubMedCrossRefGoogle Scholar
  25. 25.
    Lehle, L., Eur. J. Biochem., 109, 589 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© The Human Press Inc. 1983

Authors and Affiliations

  • Odd Nygård
    • 1
  • Peter Westermann
    • 2
  1. 1.The Wenner-Gren InstituteUniversity of StockholmStockholmSweden
  2. 2.Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlin-BuchGermany

Personalised recommendations