Advertisement

Entry of Toxic Proteins into Cells

  • Odd Nygård
  • Peter Westermann
Chapter
  • 62 Downloads

Abstract

A number of toxic proteins from bacteria and plants exert their effect by entering into the cytoplasm of cells where they carry out enzymatic activity. In recent years considerable efforts have been made to elucidate how these proteins cross the membrane and enter the cytosol. To some extent this entry represents the reverse of the transport of secretory proteins. Possibly certain physiological proteins enter by the same mechanisms. Furthermore, because of the great interest at the present time in constructing hybrid toxins selective for malignant cells, more information about the way toxins enter into the cells is needed.

Keywords

Disulfide Bridge Diphtheria Toxin Toxic Protein Toxin Concentration Endocytic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baenziger, J.U., & Fiete, D. (1982) J. Biol. Chem. 257, 6007–6009.PubMedGoogle Scholar
  2. Donovan, J.J., Simon, M.I., Draper, R.K. & Montal, M., (1901) Proc. Natl. Acad. Sci. USA. 78, 172–176.CrossRefGoogle Scholar
  3. Iglewski, B.H. & Sadoff, J.C. (1979) Methods Enzymol. 60, 780–793.PubMedCrossRefGoogle Scholar
  4. Kagan, B.L., Finkelstein, A. & Colombini, M., (1981) Proc. Natl. Acad. Sci. USA. 71, 4950–4954.CrossRefGoogle Scholar
  5. Olsnes, S. & Pihl, A.,(1982) In “The molecular action of toxins and viruses”. (Eds. P. Cohen and S. van Heyningen) Elsevier/North Holland, Amsterdam, pp. 51–105.Google Scholar
  6. Olsnes, S., Reisbig, R. & Eiklid, K., (1981) J.Biol.Chem. 256 8732–8738.PubMedGoogle Scholar
  7. Olsnes, S. & Sandvig, K., (1983) In “Receptor-mediated endocytosis”, Receptors and Recognition, Series B Vol. 15 ( Eds. P. Cuatrecasas & T.F. Roth) Chapman and Hall, London, pp. 187–236.Google Scholar
  8. Pappenheimer, A.M., Jr., (1977) Ann. Rev. Biochem. 46, 69–94.PubMedCrossRefGoogle Scholar
  9. Reisbig, R., Olsnes, S. & Eiklid, K., (1981) J. Biol. Chem. 256, 8739–9744.PubMedGoogle Scholar
  10. Sandvig, K. & Olsnes, S., (1980) J. Cell Biol. 82, 828–832.CrossRefGoogle Scholar
  11. Sandvig, K. & Olsnes, S., (1982a) J. Biol. Chem. 257, 7495–7503.PubMedGoogle Scholar
  12. Sandvig, K. & Olsnes, S., (1982b) J. Biol. Chem. 257, 7504–7513.Google Scholar
  13. Sandvig, K., Sundan, A. & Olsnes, S., (1983) J. Cell Biol. Submitted.Google Scholar
  14. Van Ness, B.G., Howard, J.B. & Bodley, J.W. (1980) J. Biol. Chem. 255, 10710–10716PubMedGoogle Scholar

Copyright information

© The Human Press Inc. 1983

Authors and Affiliations

  • Odd Nygård
    • 1
  • Peter Westermann
    • 2
  1. 1.The Wenner-Gren InstituteUniversity of StockholmStockholmSweden
  2. 2.Central Institute of Molecular BiologyAcademy of Sciences of GDRBerlin-BuchGermany

Personalised recommendations