A number of toxic proteins from bacteria and plants exert their effect by entering into the cytoplasm of cells where they carry out enzymatic activity. In recent years considerable efforts have been made to elucidate how these proteins cross the membrane and enter the cytosol. To some extent this entry represents the reverse of the transport of secretory proteins. Possibly certain physiological proteins enter by the same mechanisms. Furthermore, because of the great interest at the present time in constructing hybrid toxins selective for malignant cells, more information about the way toxins enter into the cells is needed.
KeywordsDisulfide Bridge Diphtheria Toxin Toxic Protein Toxin Concentration Endocytic Vesicle
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