Effect of Elongation Inhibitors on the Accuracy of Poly(U) Translation
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In view of the fact that numerous steps are involved in protein synthesis, the number of translational errors occurring in vivo is surprisingly low. It now seems clear that translational errors involve either a mismatching at the codon-anticodon level (Edelman and Gallant, 1977) or a mischarging of tRNA (Loftfield and Vandervagt, 1972). In the poly(Phe) synthesizing system which is extensively used in translational fidelity studies, the latter possibility is minimal since the two amino acids Phe and Leu are widely different in structure. Recent work has revealed several important factors governing the fidelity of in vitro polypeptide synthesis. The nature and concentration of the polycations present for example, are important.
KeywordsRibosomal Subunit Translational Error Translational Accuracy Polypeptide Synthesis Lational Accuracy
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