Evolution of Ribosomal Structure and Function
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Ribosomes from all organisms have similar three-dimensional structures and functional domains. They are generally subdivided into two domains, each associated with a set of specific functions (Bernabeu and Lake 1982). Ribosomes contain a Translational Domain consisting of the apparatus for reading the message and an Exit Domain that is the site of emergence of the nascent protein chain and of membrane binding. The locations of these sites within the general scheme of ribosomal organization is shown in Figure 1.
KeywordsSmall Subunit Rough Endoplasmic Reticulum Exit Site Ribosomal Structure Peptidyl Transferase
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- Bernaheu, C., Tobin, E.M., Fowler, A., Zabin, I. and Lake, J.A. (1933) J. Cell Biol. 96, 1971–1974.Google Scholar
- Lake, J.A. (1931) Sci. American 295, 87–97.Google Scholar
- Lake, J.A., Hinderson, E., Clark, M. and Matheson, A.T. (1932) Proc. Nat. Acad. Sci. U.S.A. 79, 5943–5952.Google Scholar
- Matheson, A.T., Nazar, R.N., Willick, G.E. and Yaguchi, M. (1930) In: Genetics and Evolution of RNA Polymerases, tRNA and Ribosomes (Osawa, et al, eds.) pp 625–645, University of Tokyo Press.Google Scholar