Abstract
EAE in rodents has been the most widely-studied research analog of human demyelinating disease, especially multiple sclerosis. However, accumulating evidence indicates that classical, axon-sparing demyelination cannot be solely responsible for typical behavioral deficits during EAE. The puzzle of clinical pathologic correlation during EAE in rodents is reviewed, emphasizing the discrepancy between the consistent occurrence of “ascending” hind paralysis and the variability of histopathologic changes in the central nervous system (CNS). Several alternative hypotheses of the cause of paralysis during EAE are briefly discussed, including a recently-developed theory based on functional disturbance of peripheral nodes of Ranvier in nerve root myelinated fibers. It is argued that such a theory has definite advantages in explaining typical clinical signs of EAE in rodents.
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References
Alvord, E.C. (1949). J. Immunol. 64, 355.
Bieger, D. and White, S.R. (1981). Neuroscience 6, 1745.
Bolton, C. and Cuzner, M.L. (1980). In “The suppression of experimental allergic encephalomyelitis and multiple sclerosis” (Davison, A.N. and Cuzner, M.L. Eds.) p. 189, Academic Press, New York.
Bornstein, M.B. and Crain, S.M. (1965). Science 148, 1242.
Bostock, H. and Sears, T.A. (1978). J. Physiol. ( Lond ). 280, 273.
Brown, A., McFarlin, D.E. and Raine, C.S. (1982). Lab. Invest. 46 (2), 171.
Carnegie, P.R. (1971). Nature (Lond). 229, 25.
Carnegie, P.R. and Linthicum, D.S. (1979). In “The Menarini Series on immunopathology. Vole 2” (Miescher, P.A. Ed.) p. 61, Schwabe and Co. Ltd., Basel.
Carnegie, P.R., Mackay, I.R. and Coates, A.S. (1976). In Int. Symp. on the aetiology and pathogenesis of the demyelinating diseases Sept. 1973 Kyoto (Shiraki, H. et al, Eds.) Jap. Soc. Neuropathol., p. 275, Japan Science Press, Tokyo.
Cuzner, M.L. and Davison, A.N. (1979). “The scientific basis of multiple sclerosis”: Molec. Aspects Med. Vol. 2 p. 147, Pegamon Press Ltd. U.K.
Feldman, S.,Tal, C. and Behar, A.J. (1969). J. Neurol. Sci. 8, 413.
Freund, J., Stern, E.R. and Pisani, T.M. (1947). J. Immunol. 57, 179.
Gottesfeld, Z., Teitelbaum, D., Webb, C. and Arnon, R. (1976). J. Neurochem. 27, 695.
Hoffman, P.M., Gaston, D.D. and Spitler, L.E. (1973). Clin. Immunol. Immunopathol. 1, 364.
Kabat, E.A., Wolf, A. and Bezer, A.E. (1947). J. exp. Med. 85, 117.
Kies, M.W. and Alvord, E.C. (1959) (Eds.) “Allergic encephalomyelitis”, p. 293. Thomas, Springfield, 111.
Kopeloff, L.M. and Kopeloff, N. (1947). J. Immunol. 57, 229.
Lampert, P.W. (1965). J. Neuropath exp. Neurol. 24, 371.
Lassmann, H. and Wisnievski, H.M. (1978). Acta Neuropathol. (Berl.) 43, 35.
Lassmann, H. and Wisniewski, H.M. (1979a). Brain Res. 169, 357.
Lassmann, H. and Wisniewski, H.M. (1979b). Arch. Neurol. 36, 490.
Lassman, H., Kitz, K. and Wisniewski, H.M. (1980a). In “Search for the cause of multiple sclerosis and other chronic diseases of the central nervous system: proc 1st int. Hertie symp., Frankfurt, 1979”. P. 96. Verlag Chemie, Weinheim.
Lassmann, H., Kitz, K. and Wisniewski, H.M. (1980b). Acta Neuropathol. (Berl.). 51, 191
Lassmann, H., Kitz, K. and Wisniewski, H.M. (1981). J. Neurol Sci. 50, 109.
Lennon, V.A. (1972). Cellular humoral immune responses in experimental autoimmune encephalomyelitis. PhD Thesis, University of Melbourne (unpublished).
Levine, S. (1971) „ Res. Publ. Ass. nerv. ment. Dis. 49, 33.
Levine, S. (1974a). In Report and recommendations of the National Advisory Commission on multiple sclerosis (Vol. 2 p. 213 ) US Dept. of Health, Educ. Welfare Publ.
Levine, S. (1974b). Acta Neuropathol. (Berl.) 28, 179.
Levine, S. and Sowinsky, R. (1980). Am. J„ Pathol. 101, 375.
Levine, S., Sowinsky, R., Shaw, C. and Alvord, E.C. (1975). J. Neuropathol. exp. Neurol. 34, 501.
Lipton, M.M. and Freund, (1953). J. Immunol. 71, 98.
Lublin, F.D., Maurer, P.H., Berry, R.G. and Tippett, D. (1981). J. Immunol. 126, 819.
Ludwin, S.K. (1981). In Demyelinating disease: basic and clinical electrophysiology (Waxman, S.G. and Ritchie, J.M. Eds.) p. 123. Raven Press, New York
McFarlin, D.E., Blank, S.E. and Kibler, R.F. (1974). J. Immunol. 113 (3) 712.
Olitsky, P.K. and Yager, R.H. (1949). Proc. Soc. exp. biol. Med. 70, 600.
Panicch, H. and Ciccone, C. (1981). Ann. Neurol. 9, 433.
Paterson, P.Y. (1976). Fed. Proc. 35, 2428.
Paterson, P.Y. (1982). Fed. Proc. 41, 2569.
Paterson, P.Y. Drobish, D.G., Hanson, M.A. and Jacobs, A.F. (1970). Int. Arch. Allergy 37, 26.
Piliero, S.J. and Cremonese, P. (1973). J. Reticuloendothel. Soc. 14, 100.
Poser, C.M. (1979). Med. Clin. North Am. 63, 729.
Poser, C.M. (1980). Arch. Neurol. 37, 471.
Raine, C.S. and Stone, S.H. (1977). N.Y. State J. Med. 77, 1693.
Raine, C.S., Snyder, D.H., Valsamis, M.P. and Stone, S.H. (1974). Lab. Invest. 31, 369.
Raine, C.S., Traugott, U., Nussenblatt, R.B. and Stone, S.H. (1980). Lab. Invest. 42, 327.
Raine, C.S., Traugott, U., Faroog, M., Bornstein, M.B. and Norton, W.T. (1981). Lab. Invest. 45, 174.
Ritchie, J.M. and Rogart, R.B. (1977). Proc. Natl. Acad. Sei. USA, 74, 211.
Saragea, M., Clopotaru, M., Sica, M. et al (1965). Med. Pharmacol, exp. 13, 74.
Schauf, C.L. and Davis, F.A. (1981). In “Demyelinating disease: basic and clinical electrophysiology” (Waxman, S.G. and Ritchie, J.M. Eds.) p. 267 Raven Press, New York.
Schwerer, B., Lassraann, H.; Kitz, K. et al (1981). Acta Neuropathol. (Berl.) Suppl. 7, 165.
Seil, F.J. (1981). In “Demyelinating disease: basic and clinical electrophysiology” (Waxman, S.G. and Ritchie, J.M. Eds.) p. 281 Raven Press, New York
Simmons, R.D., Bernard, C.C.A., Ng, K.T. and Carnegie, P.R. (1981). Brain Res. 215, 103.
Simmons, R.D., Bernard, C.C.A., Singer, G. and Carnegie, P.R. (1982). J. Neuroimmunol. 3, 307
Smith, M.E. (1966). Nature (Lond.) 209, 1031.
Stone, S.H. and Lerner, E.M. (1965). Ann. N.Y. Acad. Sci. 122, 227.
Stone, S.H., Lerner, E.M. and Goode, J.H, (1969). Proc. Soc. exp. biol. Med. 132, 341.
Tokioka, T. (1973). Okajimas Fol. Anat, Jap. 50, 133.
Turecky, L., Liska, B. and Pechan, I. (1980). J. Neurochem. 35, 735.
Wajda, I.J. (1972). In “Handbook of Neurochemistry Vol. 7” (Lajtha, A; Ed.) p. 221, Plenum Press, New York.
Waksman, B.H. and Adams, R.D. (1962). Am. J. Pathol. 41, 135.
Waxman, S.G. (1981). In Demyelinating disease: basic and clinical electrophysiology (Waxman, S.G. and Ritchie, J.M. Eds.) p. 169, Raven Press, New York.
Weinstock, M., Shohan-Moshanov, S., Teitelbaum, D. and Arnon, R. (1977). Brain Res. 125, 192.
White, S.R. (1979). Brain Res. 177, 157.
White, S.R. and Bieger, D. (1980). Res. Comm. Chem. Pathol. Pharmac. 30, 269.
White, S.R., White, F.P., Barnes, C.D. and Albright, J.F. (1973). Brain Res. 58, 251.
Wisniewski, H.M. and Keith, A.B. (1977). Ann. Neurol. 1, 144.
Wisniewski, H.M., Oppenheimer, D. and McDonald, W.T. (1976), J. Neuropath, exp. Neurol. 35, 327 (Abstract).
Woollam, D.H.M. and Millen, J.W. (1955). J.Neurol. Neurosurg. Psychiat. 18, 97.
Yasuda, T., Tsumita, T., Nagai, Y., Mitsuzawa, E. and Ohtani, S. (1975). Jap. J. exp. Med. 45, 423.
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Simmons, R.D., Bernard, C.C.A., Carnegie, P.R. (1983). Factors Underlying Ascending Paralysis in Rodents During Experimental Autoimmune Encephalomyelitis (EAE). In: Kidman, A.D., Tomkins, J.K., Morris, C.A., Cooper, N.A. (eds) Molecular Pathology of Nerve and Muscle. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5308-2_7
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