Abstract
The nervous system is very sensitive to perturbation by genetic and environmental factors due to the complexity of cellular interactions occurring during development. Basic mechanisms responsible for these interactions can be investigated in a simple experimental model like the visual system of Amphibia. The possible role of brain visual centres in promoting the growth of retinofugal axons was studied by grafting ectopic eyes above the spinal cord of Xenopus embryos. The reciprocal effect of ingrowing optic axons on the differentiation of visual centres in the brain was studied by removing both eye vesicles. A working hypothesis on reciprocal interactions between neuronal sets in the developing brain is proposed. Genetic information, morphogenetic characteristics of the embryonic environment, production of diffusable tropic substances and transynaptic induction, all seem to participate, at different stages, to the co-ordinated development of different regions of the brain.
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Giorgi, P.P. (1983). Interaction Between Neuronal Sets During Brain Development. In: Kidman, A.D., Tomkins, J.K., Morris, C.A., Cooper, N.A. (eds) Molecular Pathology of Nerve and Muscle. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5308-2_4
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DOI: https://doi.org/10.1007/978-1-4612-5308-2_4
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