Abstract
Ultrastructural studies of plasma lipoproteins isolated from Duchenne muscular dystrophy patients revealed marked size variations in both very low density lipoproteins and low density lipoproteins; the former being smaller than control samples whilst the latter were larger. No significant variations were observed in high density lipoproteins. Plasma lipid levels and the activities of lipoprotein lipase and lecithin:cholesterol acyltransferase were comparable in dystrophic patients and controls and also in carrier females and controls. Although plasma vitamin A levels were comparable in all samples, significantly reduced levels of β-carotene and tocopherols were found in dystrophic samples compared with controls. The present results support the proposal that the transport function of the plasma lipoproteins may be impaired in Duchenne patients.
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Austin, L., Arthur, H., Iannello, R., Jeffrey, P.L. (1983). Lipoproteins in Plasma of Duchenne Muscular Dystrophy Patients and Female Carriers. In: Kidman, A.D., Tomkins, J.K., Morris, C.A., Cooper, N.A. (eds) Molecular Pathology of Nerve and Muscle. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5308-2_26
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DOI: https://doi.org/10.1007/978-1-4612-5308-2_26
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