Toxic Effects of Glutamic Acid Analogues on Retinal Neurons
The toxic effects of kainic acid and N-methyl-D-aspartic acid on chicken retinal neurons are described. Kainic acid appears to directly kill horizontal cells and OFF-bipolar cells, and to indirectly kill amacrine cells. N-methyl-D-aspartic acid destroys amacrine cells alone. Evidence is presented suggesting that there are two types of kainic acid-preferring receptors in vertebrate retina, one linked to hyperpolarizing and one linked to depolarizing responses. The implications of the results for retinal transmitter circuitry and for the mode of action of kainic acid are discussed.
KeywordsToxicity Glycine Retina Neurol NMDA
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