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Toxic Effects of Glutamic Acid Analogues on Retinal Neurons

  • Ian G. Morgan
Part of the Experimental and Clinical Neuroscience book series (ECN)

Abstract

The toxic effects of kainic acid and N-methyl-D-aspartic acid on chicken retinal neurons are described. Kainic acid appears to directly kill horizontal cells and OFF-bipolar cells, and to indirectly kill amacrine cells. N-methyl-D-aspartic acid destroys amacrine cells alone. Evidence is presented suggesting that there are two types of kainic acid-preferring receptors in vertebrate retina, one linked to hyperpolarizing and one linked to depolarizing responses. The implications of the results for retinal transmitter circuitry and for the mode of action of kainic acid are discussed.

Keywords

Excitatory Amino Acid Bipolar Cell Kainic Acid Amacrine Cell Plexiform Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press inc. 1983

Authors and Affiliations

  • Ian G. Morgan
    • 1
  1. 1.Department of Behavioural BiologyR.S.B.S. Australian National UniversityAustralia

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