Abstract
The toxic effects of kainic acid and N-methyl-D-aspartic acid on chicken retinal neurons are described. Kainic acid appears to directly kill horizontal cells and OFF-bipolar cells, and to indirectly kill amacrine cells. N-methyl-D-aspartic acid destroys amacrine cells alone. Evidence is presented suggesting that there are two types of kainic acid-preferring receptors in vertebrate retina, one linked to hyperpolarizing and one linked to depolarizing responses. The implications of the results for retinal transmitter circuitry and for the mode of action of kainic acid are discussed.
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References
Adolph, A., Dowling, J.E., and Ehinger, B. (1980). Cell Tissue Res. 210, 269.
Ashmore, J.F., and Falk, G. (1979). Vision Res. 19, 419.
Ben-Ari, Y., Tremblay, E., Ottersen, O.P., and Naquet, R. (1979). Brain Res. 165, 362.
Biziere, K., and Coyle, J.T. (1978a). Neurosci. Lett. 8 303.
Biziere, K., and Coyle, J.T. (1978b). J. Neurochem. 31, 513.
Biziere, K., and Coyle, J.T. (1979). Neuropharmacol. 18, 409.
Brandon, C., Lam, D.M., and Wu, J.Y. (1979). Proc. Natl. Acad. Sci. USA 26, 3557.
Coyle, J.T. (1982). Trends in Neuroscience 5, 287.
Coyle, J.T., Bird, S.J., Evans, R.H., Culley, R.L., Nadler, J.V., Nicklas, W.J., and Olney, J.W. (1981). Neurosci. Res. Prog. Bull. 19, 331.
Dowling, J.E., and Ehinger, B. (1978). J. comp. Neurol. 180, 203.
Dowling, J.E., Ehinger, B., and Floren, J. (1980). J. comp. Neurol. 192, 665.
Dubin, M.W. (1970). J. comp. Neurol. 140, 479.
Dvorak, D.R., and Morgan, I.C. (1983). Neurosci. Lett. in press.
Ehrlich, D., and Morgan, l.G. (1980). Neurosci. Lett. 17, 43.
Famiglietti, E.V., and Vaughn, J.E. (1981). J. comp.Neurol. 197, 129.
Ferkany, J.W., Zaczek, R., and Coyle, J.T. (1982). Nature (Lond.) 298, 757.
Goto, M., Inomata, N., Oho, H., Saito, K.I., and Fukuda, H. (1981). Brain Res. 211, 305.
Hampton, C.K., Garcia, C. and Redburn, D.A. (1981). J. Neurosci. Res. 6, 99.
Holmgren-Taylor, I. (1982). Invest. Ophthalmol, vis. Sci. 22, 8.
Hughes, A., and Wienawa-Narkiewicz, E. (1980). Nature (Lond.) 284, 468.
Ikeda, H., and Sheardown, M.J. (1982) Neuroscience 7, 25.
Imperato, A., Porceddu, M.L., Morelli, M., Fossarello, M., and Di Chiara, G. (1981). Brain Res. 213, 205.
Ingham, C.A., and Morgan, I.G. (1983). Neuroscience, in press.
Lam, D.M.K., Su, Y.Y.T., Swain, L., Marc, R.E., Brandon, C., and Wu, J.Y. (1979). Nature (Lond.) 278, 565.
Lasater, E.M., and Dowling, J.E. (1982). Proc. Natl. Acad. Sci. USA. 79, 936.
Lessell, S., Craft, J.L., and Albert, D.M. (1980). Exp. Eye Res. 30, 731.
London, E.D. and Coyle, J.T. (1979). Mol.Pharmacol. 15, 492.
Lucas, D.R., and Newhouse, J.P. (1957). Arch. Ophthalmol. 58, 193.
McGeer, E.G., Olney, J.W., and McGeer, P.L. (1978a). Kainic Acid as a Tool in Neurobiology, (Eds.). Raven Press, New York.
McGeer, E.G., McGeer, P.L., and Singh, K. (1978b). Brain Res. 139, 381.
McLennan, H. (1981). in Glutamate as a Neurotransmitter. Di Chiara, G., and Gessa, G.L. (Eds.). Raven Press, New York, p. 253.
Morgan, I.G. (1983). in Progress in Retinal Research. Chader, G.L. and Osborne, N. (Eds.). Pergamon, Oxford, in press.
Morgan, I.G., and El-Lakany (1982). Neurosci. Lett. 34, 69.
Morgan, I.G., and Ingham, C.A. (1981). Neurosci. Lett. 21, 275.
Murakami, O., Ohtsu, K., and Shimazaki, H. (1975). Vision Res. 15, 456.
Nadler, J.V., and Cuthbertson, G.J. (1980). Brain Res. 195, 47.
Neal, M., Cunningham, J.R., James, T.A., Joseph, M., and Collins, J.F. (1981). Neurosci. Lett. 26, 301.
Nicklas, W.J., Krespan, B., and Berl, S., (1980). Eur. J. Pharmacol. 62, 209.
Olney, J.W., (1974). in Heritable Disorders of Amino Acid Metabolism. Nyham, W.H. (Ed.). John Wiley, New York, p. 501.
Retz, J.C., and Coyle, J.T., (1980). Life Sci. 27, 2495.
Rowe, J.S., and Ruddock, K.H. (1982a). Neurosci. Lett. 30, 257.
Rowe, J.S., and Ruddock, K.H., (1982b). Neurosci. Lett. 30, 251.
Schiller, P. (1982). Nature (Lond.). 297, 580.
Schwarcz, R., and Coyle, J.T. (1977). Invest. Ophthalmol. vis. Sci. 16 141.
Schwarcz, R., Scholz, D., and Coyle, J.T. (1978). Neuropharmacol. 17, 145.
Schwarcz, E.A., (1982). J. Physiol. 323, 211.
Schwob, J.E., Fuller, T., Price, J.L. and Olney, J.W., (1980). Neuroscience 5, 991.
Shiells, R.A., Falk, G. and Naghshineh, S. (1981). Nature (Lond.). 294, 592.
Slaughter, M.M., and Miller, R.F. (1981). Science 211, 182.
Streit, P., Stella, M., and Cuenod, M., (1980). Brain Res. 187, 47.
Watkins, J.C., and Evans, R.H., (1981). Ann. Rev. Pharmacol. Toxicol. 21, 165.
Yazulla, S., and Brecha, N. (1981). Proc. Natl. Acad. Sci. USA. 78, 643.
Yazulla, S., and Kleinschmidt, J. (1980). Brain Res. 182, 287.
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Morgan, I.G. (1983). Toxic Effects of Glutamic Acid Analogues on Retinal Neurons. In: Kidman, A.D., Tomkins, J.K., Morris, C.A., Cooper, N.A. (eds) Molecular Pathology of Nerve and Muscle. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5308-2_15
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DOI: https://doi.org/10.1007/978-1-4612-5308-2_15
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