Abstract
This presentation will review some of the roles of axonal transport abnormalities in the pathogeneses of axonal degenerations. Slowly evolving degeneration of peripheral nervous system or central nervous system axons occurs in a variety of human neurological diseases. Examples include heritable processes such as Friedreich’s ataxia and Charcot-Marie-Tooth Disease, sporadic disorders such as amyotrophic lateral sclerosis (motor neuron disease), and diseases caused by neurotoxins. In these disorders, the pathogenetic mechanisms responsible for the axonal changes have been conjectural. Defects in the maintenance of the axon have been hypothesized to result from abnormalities of axonal transport systems. Early studies of axonal transport in experimental models of chronic axonal disease produced conflicting and generally disappointing results, with only limited correlation between axonal transport abnormalities and axonal pathology. Rapid recent advances in understanding these processes reflect the use of more focused strategies to detect partial or selective transport defects.
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Griffin, J.W., Troncoso, J.C., Parhad, I.M., Price, D.L. (1983). Selective Defects in Axonal Transport in Neuropathological Processes. In: Kidman, A.D., Tomkins, J.K., Morris, C.A., Cooper, N.A. (eds) Molecular Pathology of Nerve and Muscle. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-5308-2_12
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