Antibody Initiates Virus Persistence: Immune Modulation and Measles Virus Infection

  • Robert S. Fujinami
  • Michael B. A. Oldstone


By antibody-induced antigenic modulation, we mean the removal of antigens from the surface of cells by specific antibody. The result is to render such cells resistant to killing by immune reagents, i.e., antibody and complement or cytotoxic lymphocytes. Stripping of surface antigens to allow cells to withstand immunologic attack was first described in the context of the thymus leukemia (TL) differentiation antigen system. TL antigen could be stripped or modulated in vivo and in vitro by anti-TL antibody (reviewed in [1]). We have expanded the concept of antibody-induced antigenic modulation as an aid to understanding several persistent infections, with our primary interest in persistent measles virus infection of humans.


Measle Virus Viral Glycoprotein Cytotoxic Lymphocyte Antiviral Immune Response Subacute Sclerosing Panencephalitis 
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Copyright information

© Springer-Verlag New York Inc. 1984

Authors and Affiliations

  • Robert S. Fujinami
  • Michael B. A. Oldstone
    • 1
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA

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