Host Range and Tissue Tropisms: Antibody-Dependent Mechanisms

  • James S. Porterfield
  • M. Jane Cardosa

Abstract

The classic concept of viral infection involves an initial interaction between determinants on the surface of a virus and cellular receptor binding sites of appropriate viral specificity, followed by stages of penetration, uncoating, and replication of the viral genome. With most infections, antiviral antibody will inhibit the initial binding step, and in so doing, will reduce viral infectivity. However, in certain cell—virus interactions, the presence of antiviral antibody increases infectivity, a phenomenon which is known as antibody-dependent enhancement, or ADE, of viral infectivity [1–4]. The explanation for this apparent paradox is that this type of infection is mediated, not by specific viral receptors, but by cellular receptors for components of the immune system that function as accessory viral receptors by binding infectious complexes of antiviral antibody with virus, this unusual binding step being followed by later replicative stages. ADE is thus conditional upon the presence on host cells of the necessary accessory receptors, but it is also determined by the nature of the infecting virus, by the specificity of the antiviral antibodies, and by the conditions under which the cells, virus, and antibody are brought together.

Keywords

Lymphoma Pancreatitis Peritonitis Encephalitis Mannose 

References

  1. 1.
    Hawkes RA, Lafferty KJ (1967) The enhancement of viral infectivity by antibody. Virology 33:250–261PubMedCrossRefGoogle Scholar
  2. 2.
    Halstead SB, O’Rourke EJ (1977) Dengue viruses and mononuclear phagocytes. 1. Infection enhancement by non-neutralizing antibody. J Exp Med 146:201–217PubMedCrossRefGoogle Scholar
  3. 3.
    Peiris JSM, Porterfield JS (1979) Antibody-mediated enhancement of flavivirus replication in macrophage-like cell lines. Nature 282:509–511PubMedCrossRefGoogle Scholar
  4. 4.
    Peiris JSM, Porterfield JS (1981) Antibody-dependent enhancement of plaque formation on cell lines of macrophage origin—a sensitive assay for antiviral antibody. J Gen Virol 57:119–125PubMedCrossRefGoogle Scholar
  5. 5.
    Unkeless JC, Fleit H, Mellman IS (1981) Structural aspects and heterogeneity of immunoglobulin Fc receptors. Adv Immunol 31:247–270PubMedCrossRefGoogle Scholar
  6. 6.
    Ryan US, Schultz RD, Ryan DR (1981) Fc and C3b receptors on pulmonary endothelial cells: Induction by injury. Science 24:557–558CrossRefGoogle Scholar
  7. 7.
    Halstead SB (1980) Immunological parameters of Togavirus disease syndrome. In Schlesinger RW (ed) The Togaviruses: Biology, Structure, Replication. Academic Press, New York, p 107Google Scholar
  8. 8.
    Peiris JSM, Gordon S, Unkeless JC, Porterfield JS (1981) Monoclonal anti-Fc receptor I blocks antibody enhancement of viral replication in macrophages. Nature 289:189–191PubMedCrossRefGoogle Scholar
  9. 9.
    Peiris JSM, Gordon S, Porterfield JS, Unkeless JC (1981) Antibody mediated enhancement of virus replication in macrophage cell lines—its dependence on the Fc receptor. In Förster O, Landy M (eds) Heterogeneity of Mononuclear Phagocytes. Academic Press, London, p 469Google Scholar
  10. 10.
    Brandt WE, Mown JM, Gentry MK, Russell PK (1982) Infection enhancement of dengue-2 virus in the U-937 human monocyte cell line by antibodies to flavivirus cross-reactive determinants. Infect Immun 36:1036–1041PubMedGoogle Scholar
  11. 11.
    Porterfield JS (1982) Immunological enhancement and the pathogenesis of dengue haemorrhagic fever. J Hyg 89:355–364CrossRefGoogle Scholar
  12. 12.
    Cardosa MJ, Porterfield JS, Gordon S (1983) Complement receptor mediates enhanced flavivirus replication in macrophages. J Exp Med 158:258–263PubMedCrossRefGoogle Scholar
  13. 13.
    Kimura T, Ueba N, Minekawa Y (1981) Studies on the mechanism of antibody-mediated enhancement of Getah virus infectivity. Biken J 24:39–45PubMedGoogle Scholar
  14. 14.
    Millican D, Porterfield JS (1982) Relationship between glycoproteins of the viral envelope of Bunyaviruses and antibody dependent plaque enhancement. J Gen Virol 63:233–236PubMedCrossRefGoogle Scholar
  15. 15.
    Clerx JPM, Horzinek MC, Osterhaus ADME (1978) Neutralisation and enhancement of infectivity of non-salmonid fish rhabdoviruses by rabbit and pike immune sera. J Gen Virol 40:297–308CrossRefGoogle Scholar
  16. 16.
    Inada T, Chong KT, Mims CA (1983) Enhancing antibodies in murine cytomegalovirus infection. In press.Google Scholar
  17. 17.
    Weiss RC, Scott FW (1981) Antibody-mediated enhancement of disease in feline infectious peritonitis: Comparisons with dengue haemorrhagic fever. Comp Immun Microbiol Inf Dis 4:175–189CrossRefGoogle Scholar
  18. 18.
    Halstead SB, Porterfield JS, O’Rourke EJ (1980) Enhancement of dengue virus infection in monocytes by flavivirus antisera. Am J Trop Med Hyg 29:638–642PubMedGoogle Scholar
  19. 19.
    Peiris JSM, Porterfield JS, Roehrig JT (1982) Monoclonal antibodies against the flavivirus West Nile. J Gen Virol 58:283–289PubMedCrossRefGoogle Scholar
  20. 20.
    Chanas AC, Gould EA, Clegg JCS, Varma MGR (1982) Monoclonal antibody to Sindbis virus glycoprotein El can neutralize, enhance infectivity and independently inhibit haemagglutination or haemolysis. J Gen Virol 58:37–46PubMedCrossRefGoogle Scholar
  21. 21.
    Haeffner-Cavaillon N, Klein M, Dorrington KJ (1979) Studies on the Fc receptor of the murine macrophage-like cell line P388D1. J Immunol 123:1905–1914PubMedGoogle Scholar
  22. 22.
    Prabhakar BS, Nathanson N (1981) Acute rabies death mediated by antibody. Nature 290:590–591PubMedCrossRefGoogle Scholar
  23. 23.
    Yee C, Costa J, Hamilton V, Klein G, Rabson AS (1982) Changes in the expression of Fc receptor produced by induction of Epstein-Barr virus in lymphoma cell lines. Virology 120:376–382PubMedCrossRefGoogle Scholar
  24. 24.
    Ezekowitz RAB, Bampton M, Gordon S (1983) Macrophage activation selectively enhances expression of Fc receptors for IgG2a. J Exp Med 157:807–812PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1984

Authors and Affiliations

  • James S. Porterfield
  • M. Jane Cardosa
    • 1
  1. 1.Sir William Dunn School of PathologyOxfordEngland

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