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Glycogenic Acanthosis, Hyperkeratosis, and Unusual Epithelial TUmors, Benign and Malignant

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Book cover Pathology of the Esophagus

Abstract

Elevated whitish plaques of the esophageal mucosa have long been familiar to pathologists. At times they have been reported as leukoplakia or as hyperkerotosis. Their true nature was first pointed out by Rywlin and Ortega.1 They found such plaques in all of 27 consecutive autopsies of patients over 50 (Fig. 8-1 A and B.). The plaques are composed of enlarged clear cells of the prickle cell layer, the cellular enlargement being caused by accumulations of glycogen giving them a characteristically pale or vacuolated appearance (Fig. 8-2.). The cellular enlargement produces the plaque, and thus they are not hyperplasias, although sometimes so reported. They are not associated with keratosis or with atypia. Their gross appearance is that of discrete oval slightly elevated firm whitish plaques from a few millimeters to 1.5 cm in diameter. They are usually distributed along the ridges of the longitudinal mucosal folds.

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Authors and Affiliations

  1. Hospital of the University of Pennsylvania, 19104, Philadelphia, PA, USA

    Horatio Enterline (Professor of Surgical Pathology)

  2. Kaiser-Permanente Regional Laboratory, 97015, Clackamas, OR, USA

    John Thompson

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  1. Horatio Enterline
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Enterline, H., Thompson, J. (1984). Glycogenic Acanthosis, Hyperkeratosis, and Unusual Epithelial TUmors, Benign and Malignant. In: Pathology of the Esophagus. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5216-0_8

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  • DOI: https://doi.org/10.1007/978-1-4612-5216-0_8

  • Publisher Name: Springer, New York, NY

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