Structures and Conformational Properties of Bases, Furanose Sugars, and Phosphate Groups
Because the molecular geometry and conformational properties of bases, nucleosides, and nucleotides are intrinsically related, they are discussed together in this chapter. Foundations will be laid for understanding the main structural features of the building blocks of nucleic acids which are a prerequisite for the interpretation of oligo- and polynucleotide structure. Several review articles on nucleoside and nucleotide structure and conformation have been published, describing results obtained from crystallographic studies (35,166–169) and their detailed analyses (170–172), from spectroscopic data (130,135,144,173–178) or from classical potential energy and quantum chemical calculations (70,179–182). The general physicochemical and biochemical properties of nucleosides, nucleotides, and nucleic acids are treated in several monographs and book series (123–125,183–190).
KeywordsSugar Adenosine Cytosine Guanine Thiamine
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