Abstract
Traditional approaches to circumventing the blood-brain barrier (BBB) involve intrathecal administration of neuropharmaceuticals; however, this results in drug distribution only to the surface of the brain. Another approach to circumventing the BBB involves drug latentiation or the conversion of water soluble substances to lipid soluble compounds. This approach portends a vast promise for the neuropharmaceutical industry, which has yet to be realized for a wide variety of chemotherapeutic agents. However, studies with the lipid soluble peptide, cyclosporin, indicate that drug latentiation may not be a particularly promising approach for the delivery of systemically administered neuropeptides to brain. A new strategy, called transport-directed drug delivery to brain, involves coupling of the neuropharmaceutical agent to a peptide (e.g., insulin) that is normally transported through the BBB by a peptide specific transport system.
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Pardridge, W.M. (1985). Strategies for Drug Delivery through the Blood-Brain Barrier. In: Borchardt, R.T., Repta, A.J., Stella, V.J. (eds) Directed Drug Delivery. Experimental Biology and Medicine, vol 7. Humana Press. https://doi.org/10.1007/978-1-4612-5186-6_6
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DOI: https://doi.org/10.1007/978-1-4612-5186-6_6
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