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The Use of Scintigraphic Methods for the Evaluation of Novel Delivery Systems

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Book cover Directed Drug Delivery

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 7))

Abstract

The advanced delivery systems that are being developed for future clinical use are of increasing complexity and must be evaluated extensively by in vitro and in vivo tests. It is often necessary for research, development and regulatory purposes to have direct information in the following areas:-

  1. i.

    The position or distribution of the delivery system in the body

  2. ii.

    The integrity of the delivery system

  3. iii.

    The in vivo release characteristics

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References

  • Bond, S.W., Hardy, J.G. and Wilson, C.G., Deposition and clearance of nasal sprays, Proc. Second European Congress Biopharmaceutics and Pharmacokinetics, I, 1984, 93–98.

    Google Scholar 

  • Casey, D.L., Beihn, R.M., Digenis, G.A. and Shambu, M.B., Method for monitoring hard gelatin capsule disintegration times in humans using external scintigraphy, J. Pharm. Sci., 65 (1976) 1412–1413.

    Article  PubMed  CAS  Google Scholar 

  • Counsell, R.E. and Ice, The design of organ imaging radiopharmaceuticals, In Ariens, A.J. (Ed.), Drug Design, Vol. 4, Academic Press, New York, 1975, pp 172–259.

    Google Scholar 

  • Davis, S.S., The use of scintigraphic methods for the evaluation of drug dosage forms in the gastrointestinal tract, In Breimer, D.D. and Speiser, P. (Eds.), Topics in Pharmaceutical Sciences, 1983, Elsevier, Amsterdam, 1983, pp 205–215.

    Google Scholar 

  • Davis, S.S., The use of scintigraphic methods for the evaluation of drug dosage forms in the gastrointestinal tract, In Breimer, D.D. and Speiser, P. (Eds.), Topics in Pharmaceutical Sciences, 1983, Elsevier, Amsterdam, 1983, pp 205–215.

    Google Scholar 

  • Davis, S.S., The use of scintigraphic methods for the evaluation of drug dosage forms in the gastrointestinal tract, In Breimer, D.D. and Speiser, P. (Eds.), Topics in Pharmaceutical Sciences, 1983, Elsevier, Amsterdam, 1983, pp 205–215.

    Google Scholar 

  • Davis, S.S., The use of scintigraphic methods for the evaluation of drug dosage forms in the gastrointestinal tract, In Breimer, D.D. and Speiser, P. (Eds.), Topics in Pharmaceutical Sciences, 1983, Elsevier, Amsterdam, 1983, pp 205–215.

    Google Scholar 

  • Digenis, G.A., The utilisation of short-lived radionuclides in the assessment of formulation and in vivo deposition of drugs, In Wilson, C.G., Hardy, J.G., Frier, M. and Davis, S.S. (Eds.), Radionuclide Imaging in Drug Research, Croom Helm, London, 1982, pp 103–143.

    Google Scholar 

  • Doyle, M., Rzedzian, R., Mansfield, P. and Coupland, R.E., Dynamic NMR cardiac imaging in a piglet, Brit. J. Radiol., 56 (1983) 925–930.

    Article  CAS  Google Scholar 

  • Hardy, J.G. and Wilson, C.G., Radionuclide imaging in pharmaceutical, physiological and pharmacological research, Clin. Phys. Physiol. Meas., 2 (1981) 71–121.

    Article  PubMed  CAS  Google Scholar 

  • Illum, L. and Davis, S.S., Specific intravenous delivery of drugs to the lungs using ion-exchange microspheres, J. Pharm. Pharmac., 34 Suppl. (1982) 89 P.

    Article  Google Scholar 

  • Ilium, L. and Davis, S.S., The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338), FEBS Letters, 167 (1984a) 79–82 (1984).

    Article  Google Scholar 

  • Ilium, L. and Davis, S.S., The kinetics of uptake and organ distribution of colloidal drug carrier particles delivered to rabbits, Proc. Second European Congress on Biopharmaceutics and Pharmacokinetics, II, 1984b, 97.

    Google Scholar 

  • Ilium, L., Hardy, J.G., Wilson, C.G. and Davis, S.S., Gamma ray detection probe for the evaluation of blood activity-time profiles, J. Pharm. Pharmac., 34 Suppl. (1982a) 90 P.

    Article  Google Scholar 

  • Ilium, L., Davis, S.S., Wilson, C.G., Frier, M., Hardy, J.G. and Thomas, N.W., Blood clearance and organ deposition of intravenously administered colloidal particles: the effects of particle size, nature and shape, Intern. J. Pharmaceut., 12 (1982b), 135–146.

    Article  Google Scholar 

  • Jay, M., Beihn, R.M., Syder, G.A., McClanahan, J.S., Digenis, G.A., Caldwell, L. and Mlodozeniec, A., In vitro and in vivo suppository studies with perturbed angular correlation and external scintigraphy, Intern. J. Pharmaceut., 14 (1983) 343–347.

    Article  CAS  Google Scholar 

  • Kelly, J.D., Choice of radionuclides for scintigraphy, In Wilson, C.G., Hardy, J.G., Frier, M. and Davis, S.S. (Eds.), Radionuclide Imaging in Drug Research, Croan Helm, London, 1982, pp 39–59.

    Google Scholar 

  • Kelly, J.D., Choice of radionuclides for scintigraphy, In Wilson, C.G., Hardy, J.G., Frier, M. and Davis, S.S. (Eds.), Radionuclide Imaging in Drug Research, Croan Helm, London, 1982, pp 39–59.

    Google Scholar 

  • Malton, C.A., Biopharmaceutical Studies on Inhalation Aerosols, PhD Thesis, CNAA.

    Google Scholar 

  • Malton, C.A., Hallworth, G.W., Padfield, J.M., Perkins, A., Wilson, C.G. and Davis, S.S., Deposition and clearance of inhalation aerosols in dogs and rabbits using a gamma camera, J. Pharm. Pharmac., 34 Suppl., 1982, 64 P.

    Article  Google Scholar 

  • Mauk, M.R., Gamble, R.C. and Baldeschweiler, J.D., Targeting of lipid vesicles: specificity of carbohydrate receptor analogues for leukocytes in mice, Proc. Natl. Acad. Sci. USA, 77 (1980) 4430–4434.

    Article  PubMed  CAS  Google Scholar 

  • Short, M.D., Use of a 77Br-labelled broncho-dilating drug in healthy and asthmatic subjects, Brit. J. Radiol., 56 (1983) 507.

    Google Scholar 

  • Wilson, C.G., Hardy, J.G., Frier, M. and Davis, S.S. (Eds.), Radionuclide Imaging in Drug Research, Croan Helm, London, 1982, pp 330.

    Google Scholar 

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© 1985 The Humana Press Inc.

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Davis, S.S. (1985). The Use of Scintigraphic Methods for the Evaluation of Novel Delivery Systems. In: Borchardt, R.T., Repta, A.J., Stella, V.J. (eds) Directed Drug Delivery. Experimental Biology and Medicine, vol 7. Humana Press. https://doi.org/10.1007/978-1-4612-5186-6_18

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  • DOI: https://doi.org/10.1007/978-1-4612-5186-6_18

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9603-4

  • Online ISBN: 978-1-4612-5186-6

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