Drug Delivery via Cell-Surface Receptors

  • T. Y. Shen
Part of the Experimental Biology and Medicine book series (EBAM, volume 7)


Cell-surface receptors are noted for their high degree of specificity in their interactions with appropriate ligands. In receptor mediated drug delivery the drug is attached to or associated with a ligand which recognizes a specific receptor on the surface of a target cell. The ligand can be a component of a phospholipid vesicle, e.g. liposome, a lipoprotein particle or a chemical derivative of a macromolecule, small peptide or oligosaccharide (Fig. 1). After ingestion the active free drug is liberated by intracellular enzymes to exert its pharmacological effect.


Kupffer Cell Enzyme Replacement Therapy Native Enzyme Receptor Mediate Endocytosis Mannose Receptor 
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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • T. Y. Shen
    • 1
  1. 1.Merck Sharp & Dohme Research LaboratoriesRahwayUSA

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