Abstract
The approach described in this chapter is an exploration of the possibility of using macromolecule-drug conjugate for directed delivery of therapeutic agents. Since active targeting such as antibody or receptor-mediated delivery will be mentioned in other chapters, discussions will be limited to the use of conjugates in which a drug is associated or covalently bound to a non-specific macro-molecular carrier. Emphasis will be placed on the results of dextran-conjugated mitomycin C obtained in our labolatory because they serve nicely to illustrate important considerations in the design of macromolecular conjugate and appear be practical for use in human cancer chemotherapy.
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Sezaki, H., Hashida, M. (1985). Macromolecules as Drug Delivery Systems. In: Borchardt, R.T., Repta, A.J., Stella, V.J. (eds) Directed Drug Delivery. Experimental Biology and Medicine, vol 7. Humana Press. https://doi.org/10.1007/978-1-4612-5186-6_11
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DOI: https://doi.org/10.1007/978-1-4612-5186-6_11
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