Summary
The sources of arachidonic acid for the production of prostanoids during early labor have been identified as (diacyl)phosphatidylethanolamine and phosphatidylinositol. The enzymatic mechanisms that account for the selective mobilization of arachidonic acid in amnion tissue from these two glycerophospholipids are described. Based on the activation/inhibition of the enzymes involved in these processes, we suggest a central role for \(C{{a}^{{{{2}^{ + }}}}}\) in the regulation of prostanoid biosynthesis in this tissue. Platelet-activating factor (PAF) has been identified in amniotic fluid from women in labor, in the urine and tracheal fluid of the newborn, and in amnion tissue. Increased PAF concentrations were found in the amnion tissue obtained at term from women in labor. PAF biosynthesis and hydrolysis has been demonstrated in amnion tissue. LysoPAF:acetylCoA acetyltransferase was activated by \(C{{a}^{{{{2}^{ + }}}}}\) at micromolar concentrations. A biochemical model for the regulation of arachidonic acid release and prostanoid formation in relation to parturition is presented.
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Johnston, J.M., Ban, C., Anceschi, M.M. (1985). Regulation of Arachidonic Acid Release for Prostaglandin Production during Parturition. In: Bleasdale, J.E., Eichberg, J., Hauser, G. (eds) Inositol and Phosphoinositides. Experimental Biology and Medicine, vol 6. Humana Press. https://doi.org/10.1007/978-1-4612-5184-2_32
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DOI: https://doi.org/10.1007/978-1-4612-5184-2_32
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