Inositol Trisphosphate and Calcium Mobilization

Berridge, Michael J.; Irvine, Robin F.

doi:10.1007/978-1-4612-5184-2_23

Michael J. Berridge⁴ &
Robin F. Irvine⁵

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 6))

50 Accesses
2 Citations

Summary

Receptors that mobilize calcium stimulate the hydrolysis of phosphoinositides. Addition of 5-HT to the fly salivary gland causes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂). The resulting increases in inositol 1,4,5-trisphosphate (IP₃) and inositol 1,4-bisphosphate (I P₂) that begin to accumulate with no apparent delay is fast enough to account for the calcium-dependent component of the physiological response. In contrast, the levels of inositol 1-phosphate (I P) and free inositol begin to rise with lag periods of 20 and 60 seconds respectively. This analysis of how fast these inositol phosphates accumulate following stimulation is consistent with the idea that the primary action of hormones is to hydrolyse PIP₂ to diacylglycerol and IP₃. The idea that IP₃ may function as a second messenger to mobilize intracellular calcium has been supported by observations on pancreatic and liver cells with ‘leaky’ plasma membranes. Addition of IP₃ in the micromolar range induces a release of calcium from an internal membrane pool that is most likely located in the endoplasmic reticulum. The effect of IP₃ appears to be specific in that there was no release in response to IP₂, IP or inositol 1,2-cyclic phosphate. It is proposed that the IP₃ might be the long sought-after second messenger that functions to mobilize intracellular calcium.

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Authors and Affiliations

A.F.R.C. Unit of Insect Neurophysiology and Pharmacology Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Michael J. Berridge
A. F. R. C. Institute of Animal Physiology, Babraham, UK, CB2 4AT
Robin F. Irvine

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Michael J. Berridge
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Department of Biochemistry, University of Texas Health Science Center, Dallas, Texas, USA
John E. Bleasdale
Department of Biochemical and Biophysical Sciences, University of Houston, Houston, Texas, USA
Joseph Eichberg
Ralph Lowell Laboratories, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
George Hauser

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Berridge, M.J., Irvine, R.F. (1985). Inositol Trisphosphate and Calcium Mobilization. In: Bleasdale, J.E., Eichberg, J., Hauser, G. (eds) Inositol and Phosphoinositides. Experimental Biology and Medicine, vol 6. Humana Press. https://doi.org/10.1007/978-1-4612-5184-2_23

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DOI: https://doi.org/10.1007/978-1-4612-5184-2_23
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9602-7
Online ISBN: 978-1-4612-5184-2
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