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Microencapsulation and Artificial Cells pp 267–272Cite as

A Controlled-Release Anti-Inflammatory Drug

Studies on Microcapsules

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Abstract

A procedure to obtain a controlled-release microencapsulated anti-inflammatory drug based on a solvent evaporation method is described. The present method makes use of ethylcellulose as the polymer and methylene chloride as solvent. The evaporation of solvent is controlled by means of an air stream. Variations in the preparative procedure and their effects on capsule dimensions and permeabilities were studied. The release behavior of the drug is determined, and two different diffusion constants are also determined: 7.0 × 10−10 cm2/s and 1.2 × 10−10 cm2/s, corresponding to low and high release time. Based on these results it is proposed that these microcapsules have a nonhomogeneous polymeric wall, and are more porous in the outer surface. This model might be applicable to the microcapsules obtained by means of the solvent evaporation method.

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Author information

Authors and Affiliations

  1. Instituto Nacional de Tecnologia Industrial, Argentina

    C. Cristallini, G. Enriquez De Grassi, L. Guardines & R. Gaussmann

Authors
  1. C. Cristallini
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  2. G. Enriquez De Grassi
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  3. L. Guardines
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  4. R. Gaussmann
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Editor information

Editors and Affiliations

  1. Artificial Cells and Organ Research Center, McGill University, Montreal, Quebec, Canada

    T. M. S. Chang MD, PhD, FRCP (C) (Professor of Physiology and of Medicine, and Director) (Professor of Physiology and of Medicine, and Director)

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© 1984 The Humana Press Inc.

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Cristallini, C., Enriquez De Grassi, G., Guardines, L., Gaussmann, R. (1984). A Controlled-Release Anti-Inflammatory Drug. In: Chang, T.M.S. (eds) Microencapsulation and Artificial Cells. Humana Press. https://doi.org/10.1007/978-1-4612-5182-8_31

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  • DOI: https://doi.org/10.1007/978-1-4612-5182-8_31

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9601-0

  • Online ISBN: 978-1-4612-5182-8

  • eBook Packages: Springer Book Archive

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