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Kinetic Model identification of Drug Release from Microcapsules Using the Nonlinear Regression Search Procedure

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Book cover Microencapsulation and Artificial Cells

Abstract

Drug release from microcapsules has been shown by several investigators to follow either a square-root-of-time equation (1,2) or a first-order kinetic equation (3,4). Other authors (5) have found that the kinetic data from microcapsules agree both with first-order and square-root-of-time equations. Application of the differential rate treatment (6) was needed in order to distinguish between the two kinetic release models. It was found that kinetic data actually conformed with the first-order equation.

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References

  1. Jalsenjak, I., Nixon, J. R., Senjkovic, R., and Stivic, I. (1980), J. Pharm. Pharmacol. 32, 678.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, P.O.B. 12065, Jerusalem, 91120, Israel

    S. Benita

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  1. S. Benita
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Editor information

Editors and Affiliations

  1. Artificial Cells and Organ Research Center, McGill University, Montreal, Quebec, Canada

    T. M. S. Chang MD, PhD, FRCP (C) (Professor of Physiology and of Medicine, and Director) (Professor of Physiology and of Medicine, and Director)

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© 1984 The Humana Press Inc.

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Benita, S. (1984). Kinetic Model identification of Drug Release from Microcapsules Using the Nonlinear Regression Search Procedure. In: Chang, T.M.S. (eds) Microencapsulation and Artificial Cells. Humana Press. https://doi.org/10.1007/978-1-4612-5182-8_28

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  • DOI: https://doi.org/10.1007/978-1-4612-5182-8_28

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9601-0

  • Online ISBN: 978-1-4612-5182-8

  • eBook Packages: Springer Book Archive

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