Abstract
One method to increase the retention time of hemoglobin (Hgb) is to react it with a hydroxyethyl starch (HES) molecule. To examine this hypothesis, polymer-bound hemoglobin compounds were synthesized by the dialdehyde route. The electrophoretic mobility patterns indicate complete binding of the Iigb. Preliminary exchange-transfusion experiments in rates showed that they could survive for at least 10 h at Hct < 10% when transfused with 6% HES-Hgb solutions. The retention time of the Hgb in the urine was increased to 12 h with these new polymers.
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Cerny, L. C., Stasiw, D. M., Cerny, E. L., Baldwin, J. E., and Gill, B. (1982), Clin. Hemorheology 2, 355.
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© 1984 The Humana Press Inc.
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Cerny, L.C., Cerny, E.L., Robach, J., Reath, M., Pontero, L. (1984). A Blood Substitute from Hydroxyethyl Starch and Hemoglobin. In: Chang, T.M.S. (eds) Microencapsulation and Artificial Cells. Humana Press. https://doi.org/10.1007/978-1-4612-5182-8_17
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DOI: https://doi.org/10.1007/978-1-4612-5182-8_17
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