Abstract
The idea of microencapsulating a solution of hemoglobin (Hb) to make a prototypal artificial red blood cell (RBC) has been around for decades. T.M.S. Chang discussed the possibility in the late 50s and early 60s. The ideal properties and characteristics of a transfusable suspension of microencapsulated Hb have been specified. Progress has been limited by three major obstacles: (i) selecting an acceptable microencapsulation material; (ii) developing a microencapsulation process that yields the desired size range, but avoids denaturation of Hb; and (iii) encapsulating sufficient Hb while maintaining an acceptable final viscosity. We have made considerable progress in all three fronts. The resulting microcapsules are called Neohemocytes.
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© 1984 The Humana Press Inc.
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Hunt, C.A., Burnette, R.R. (1984). Lipid Microencapsulation of Hemoglobin. In: Chang, T.M.S. (eds) Microencapsulation and Artificial Cells. Humana Press. https://doi.org/10.1007/978-1-4612-5182-8_16
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DOI: https://doi.org/10.1007/978-1-4612-5182-8_16
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9601-0
Online ISBN: 978-1-4612-5182-8
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