Skip to main content
SpringerLink
Log in

Cell Growth, Tissue Neogenesis, and Neoplastic Transformation

  • Chapter
Book cover Growth, Cancer, and the Cell Cycle

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 5))

Abstract

Exponential growth is rarely observed in vivo. most mammalian tissues, whether normal or malignant, exhibit nonexponential kinetics in which growth decelerates continuously with time (1–10). This deceleration is characterized by a gradual but progressive increase in a tissue’s doubling time, and a corresponding decline in its specific growth rate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Mottram, J.C. and S. Russ. 1917–1918. Proc. Roy. Soc. London Ser. B 90:1.

    Google Scholar 

  2. Mayneord, W.V. 1932. Am. J. Cancer 16:841.

    Google Scholar 

  3. Schrek, R. Am. J. Cancer 28:345.

    Google Scholar 

  4. Klein, G. and L.Revesz. 1953. J. Natl. Cancer Inst. 14:229.

    PubMed  CAS  Google Scholar 

  5. Patt, H.M. and M.E. Blackford. 1954. Cancer Res. 14:391.

    PubMed  CAS  Google Scholar 

  6. Bertallanfy, von L. 1957. Quart. Rev. Biol. 32:217.

    Article  Google Scholar 

  7. McCredie, J.A., W.R. Inch, J. Kruv, and T.A. Watson. Growth 29:331.

    Google Scholar 

  8. Lala, P.K. and H.M. Patt. 1966. Proc. Natl. Acad. Sci. 56:1735.

    Article  PubMed  CAS  Google Scholar 

  9. Laird, A.K. 1969. Natl. Cancer Inst. Monogr. #30:15.

    PubMed  CAS  Google Scholar 

  10. Simpson-Herren, L. and H.H. Lloyd. 1970. Cancer Chemotherapy Repts. 54:143.

    CAS  Google Scholar 

  11. Pearl, R. 1925. The Biology of Population Growth. Knopf, New York.

    Google Scholar 

  12. Winsor, C.P. 1932. Proc. Natl. Acad. Sci. 18:1.

    Article  PubMed  CAS  Google Scholar 

  13. Smith, F. 1952. Ecology 33:441.

    Article  Google Scholar 

  14. Rose, S.M. 1957. Biol. Rev. 32:331.

    Article  Google Scholar 

  15. Steel, G.G. 1977. Growth Kinetics of Tumors. Clarendon Press, Oxford.

    Google Scholar 

  16. Laird, A.K. 1965. Growth 29:249.

    PubMed  CAS  Google Scholar 

  17. Stebbing, A.R.D. 1981. J. Mar. Biol. Assoc. U.K. 61:35.

    Article  Google Scholar 

  18. Skehan, P. and S.J. Friedman. 1984.. Cell Tissue Kinet., in press.

    Google Scholar 

  19. Dethlefsen, L.A., J.M.S. Prewitt, and M.L. Mendelsohn. 1968. J. Natl. Cancer Inst. 40:389.

    PubMed  CAS  Google Scholar 

  20. Vaage, T. and M. Costanza. 1979. Cancer Res. 39:4466.

    PubMed  CAS  Google Scholar 

  21. Durbin, P, N. Jeung, M. Williams, and J. Arnold. 1967. Cancer Res. 27:1341.

    PubMed  CAS  Google Scholar 

  22. Simpson-Herren, L., T. Springer, A. Sanford, and J. Holmquist. 1977. Progr. Cancer Res. Therapy 5:117.

    Google Scholar 

  23. Sugarbaker, E.V., J. Thornthwaite, and A.S. Ketcham. 1977. Progr. Cancer Res. Therapy 5:227.

    Google Scholar 

  24. DeWys, W.D. 1972. Cancer Res. 32:374.

    PubMed  CAS  Google Scholar 

  25. Cox, E.B. 1978. Proc. Am. Assoc. Cancer Res. 19:184.

    Google Scholar 

  26. Weiss, P. and J.L. Kavanau. 1957. J. Gen. Physiol. 41:1.

    Article  PubMed  CAS  Google Scholar 

  27. Tanner, J.M. 1981. Brt. Med. Bull. 37:233.

    CAS  Google Scholar 

  28. Goss, R.J. 1969. In R.J. Goss (ed.) “Regulation of Organ and Tissue Growth,” pp. 1–11, Academic Press, New York.

    Google Scholar 

  29. Snow, M.H.L. 1981. Brt. Med. Bull. 37:221.

    CAS  Google Scholar 

  30. Ellis, M.M. 1909. J. Exp. Zool. 7:421.

    Article  Google Scholar 

  31. Skehan, P. and S.J. Friedman. 1982. Cancer Res. 42:1636.

    PubMed  CAS  Google Scholar 

  32. Schatten, W.E. 1958. Cancer 11:455.

    Article  PubMed  CAS  Google Scholar 

  33. Ketcham, A.S., D.L. Kinsey, H. Wexler, and N. Mantel. 1961. Cancer 14:875.

    Article  PubMed  CAS  Google Scholar 

  34. Gorelik, E., S. Segal, and M. Feldman. 1981. Int. J. Cancer 27:847.

    Article  PubMed  CAS  Google Scholar 

  35. Weiss, L., G. Poste, A. MacKearnin, and K. Willett. 1975. J. Cell Biol. 64:135.

    Article  PubMed  CAS  Google Scholar 

  36. Foulds, L. 1969. “Neoplastic Development.” Academic Press, New York.

    Google Scholar 

  37. Emmelot,P. and E. Scherer. 1980. Biochim. Biophys. Acta 605:247.

    PubMed  CAS  Google Scholar 

  38. Farber,E. and R. Cameron. 1980. Adv. Cancer Res. 31:125.

    Article  PubMed  CAS  Google Scholar 

  39. Skehan, P. 1976. Exp. Cell Res. 97:184.

    Article  PubMed  CAS  Google Scholar 

  40. Skehan, P. and S.J. Friedman. 1976. Exp. Cell Res. 101:315.

    Article  PubMed  CAS  Google Scholar 

  41. Lajtha, L. 1963. J. Cell. Comp. Physiol. 62 (Suppl. 1):143.

    Google Scholar 

  42. Gelfant, S. 1977. Cancer Res. 37:3845.

    PubMed  CAS  Google Scholar 

  43. Tumbleson, M.E., O.W. Tinsley, J.B. Mulder, and R.F. Flatt. 1970. Growth 34:401.

    PubMed  CAS  Google Scholar 

  44. McCarthy, P.H. and Butterfield, R.M. 1981. Growth 45:351.

    Google Scholar 

  45. Clark, R.G. and M.F. Tarttelin. 1978. Growth 42:113.

    PubMed  CAS  Google Scholar 

  46. Clifton, K.H. and Yatvib, M.B. 1970. Cancer Res. 30:658.

    PubMed  CAS  Google Scholar 

  47. Dombernowsky, P. and N.R. Hartmann. 1972. Cancer Res. 32:2452.

    PubMed  CAS  Google Scholar 

  48. Davis, J.M., A.K. Chan, and E.A. Thompson. 1980. J. Natl. Cancer Inst. 64:55.

    PubMed  CAS  Google Scholar 

  49. Sato, N., M. Michaelides, and M.K. Wallack. 1981. Cancer Res. 41:2267.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The University of Calgary, Calgary, Alberta, Canada

    Philip Skehan

Authors
  1. Philip Skehan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oncology Research Group and Department of Pharmacology, The University of Calgary, Calgary, Alberta, Canada

    Philip Skehan  & Susan J. Friedman  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1984 The Humana Press Inc.

About this chapter

Cite this chapter

Skehan, P. (1984). Cell Growth, Tissue Neogenesis, and Neoplastic Transformation. In: Skehan, P., Friedman, S.J. (eds) Growth, Cancer, and the Cell Cycle. Experimental Biology and Medicine, vol 5. Humana Press. https://doi.org/10.1007/978-1-4612-5178-1_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5178-1_29

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9599-0

  • Online ISBN: 978-1-4612-5178-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation