Abstract
The hepatocytes in normal adult rats are in a state of quiescence, or G0. They retain the capacity to proliferate, however, and re-enter the cell cycle in partial synchrony, responding vigorously to 2/3 hepatectomy and slightly less so to manipulations of the diet, administration of hormones, growth factors, toxic agents, and other substances. The precise physiological signals that regulate this growth remain elusive, but evidence from a number of laboratories indicates that blood-borne substances are responsible (1).
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References
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Bucher, N.L.R., Russell, W.E., McGowan, J.A. (1984). Growth Activation in Adult Rat Hepatocytes. In: Skehan, P., Friedman, S.J. (eds) Growth, Cancer, and the Cell Cycle. Experimental Biology and Medicine, vol 5. Humana Press. https://doi.org/10.1007/978-1-4612-5178-1_16
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DOI: https://doi.org/10.1007/978-1-4612-5178-1_16
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