Abstract
Alzheimer’s disease patients suffer from significant mental decline, and the capacity of these patients to provide “informed” consent can appropriately be questioned. Emotional changes accompany cognitive deterioration in the Alzheimer’s patient, and further confound the patient’s ability to make “reasoned” judgments about participation in research protocols. The magnitude and nature of these cognitive and emotional changes are of clear relevance for issues related to informed consent. Accordingly, in this chapter we will review the nature of these cognitive and emotional changes in mildly impaired, and severely impaired Alzheimer’s patients, and explore the relevance of these changes for issues related to informed consent.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Notes and References
B. Reisberg, Brain Failure: An Introduction to Current Concepts of Senility ( New York: The Free Press/Macmillan, 1981 ), pp. 81–122.
B. Reisberg and S. H. Ferris, “Diagnosis and Assessment of the Older Patient,” Hospital & Community Psychiatry, 33, 1982, 104–110.
B. Reisberg, S. H. Ferris, M. J. de Leon, and T. Crook, “The Global Deterioration Scale (GDS): An instrument for the assessment of Primary Degenerative Dementia (PDD),” American Journal of Psychiatry, 139, 1982, 1136– 1139.
B. Reisberg, S. H. Ferris, M. K. Schneck, M. J. de Leon, T. Crook, and S. Gershon, “The relationship between psychiatric assessments and cognitive test measures in mild to moderately cognitively impaired elderly,” Psychopharm Bulletin, 17, 1981, 99–101.
M. J. de Leon, S. H. Ferris, I. Blau, A. E. George, B. Reisberg, I. I. Kricheff, and S. Gershon, “Correlations between computerized tomographic changes and behavioral deficits in senile dementia,” Lancet, 11, 1979, 859.
M. J. de Leon, S. H. Ferris, A. E. George, B. Reisberg, I. I. Kricheff, and S. Gershon, “Computed tomography evaluations of brain-behavior relationships in senile dementia of the Alzheimer’s type,” Neurobiology of Aging, 1981, 69–79.
S. H. Ferris, M. J. de Leon, A. P. Wolf, T. Farkas, D. R. Christman, B. Reisberg, J. S. Fowler, R. MacGregor, A. Goldman, A. E. George, and S. Rampal, “Positron emission tomography in the study of aging and senile dementia, ” Neurobiology of Aging, 1, 1980, 127–131.
B. Reisberg, S. H. Ferris, H. Ahn, and E. R. John, “Electrophysiologic asymmetry and brain change in primary degenerative dementia,” Soc. Neurosci. (Abstracts), 7, 1981, 241.
K. Nandy, B. Reisberg, S. H. Ferris, and M. J. de Leon, “Brain reactive antibodies and progressive cognitive decline in the aged,” Journal of American Aging Association (abstract), 4, 1981, 145.
A Psychiatric Glossary,3rd Edition (Washington, DC: American Psychiatric Association, 1969), p. 28.
M. J. Martin, “Psychiatry and Other Specialties,” in A. M. Freedman, H. I. Kaplan, and B. J. Sadock, eds., Comprehensive Textbook of Psychiatry, II ( Baltimore: Williams and Williams Co., 1975 ), p. 1740.
B. Reisberg, “The office management of primary degenerative dementia,” Psychiatric Annals, 12 (6), 1982, 631–637.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press, Inc.
About this chapter
Cite this chapter
Reisberg, B., Gordon, B., McCarthy, M., Ferris, S.H. (1985). Clinical Symptoms Accompanying Progressive Cognitive Decline and Alzheimer’s Disease. In: Melnick, V.L., Dubler, N.N. (eds) Alzheimer’s Dementia. Contemporary Issues in Biomedicine, Ethics, and Society. Humana Press. https://doi.org/10.1007/978-1-4612-5174-3_3
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5174-3_3
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9597-6
Online ISBN: 978-1-4612-5174-3
eBook Packages: Springer Book Archive