Abstract
Genotoxic effects can be categorized into those that lead directly to transmissable alterations (gene mutation and certain classes of chromosomal damage) and those that are secondary to the production of heritable changes (DNA strand breakage and DNA repair processes). Both types are related and in most instances are induced by the same agents; however, as far as defining their impact on genetic disease and/or cancer initiation, the group of effects defined as “direct” measures of DNA damage is most critical to detect.
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Brusick, D.J. (1984). Consequences of Genotoxic Effects. In: Douglas, J.F. (eds) Carcinogenesis and Mutagenesis Testing. Contemporary Biomedicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5164-4_3
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DOI: https://doi.org/10.1007/978-1-4612-5164-4_3
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