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Evaluation and Interpretation of Carcinogenesis Bioassay Results

  • Cipriano CuetoJr.
Part of the Contemporary Biomedicine book series (CB, volume 4)

Abstract

Although various approaches to carcinogenesis testing have been proposed [e. g., Weisburger and Williams (1)] involving short-term in vitro tests and limited or short-term in vivo tests using a tumorigenic endpoint, chronic carcinogenesis bioassay in animals is still the method most commonly used to detect the potential carcinogenicity of chemicals to humans. These bioassay methods have various levels of sophistication, sensitivity, and predictability. The tests are usually performed in mice and rats because of their relatively short lifespan, their known historical control-tumor incidence, their cost, and their availability relative to other species. The results of these tests are used for species and dose extrapolation and as a measure, or more properly an indication, of the potential risk to humans of the compound tested, as well as a means of evaluating the relative carcinogenic activity of chemicals within a specific biological testing system.

Keywords

Test Animal Test Chemical Tumor Incidence Feed Consumption Technical Report Series 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The HAMANA Press Inc. 1984

Authors and Affiliations

  • Cipriano CuetoJr.

There are no affiliations available

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