Abstract
Although various approaches to carcinogenesis testing have been proposed [e. g., Weisburger and Williams (1)] involving short-term in vitro tests and limited or short-term in vivo tests using a tumorigenic endpoint, chronic carcinogenesis bioassay in animals is still the method most commonly used to detect the potential carcinogenicity of chemicals to humans. These bioassay methods have various levels of sophistication, sensitivity, and predictability. The tests are usually performed in mice and rats because of their relatively short lifespan, their known historical control-tumor incidence, their cost, and their availability relative to other species. The results of these tests are used for species and dose extrapolation and as a measure, or more properly an indication, of the potential risk to humans of the compound tested, as well as a means of evaluating the relative carcinogenic activity of chemicals within a specific biological testing system.
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Cueto, C. (1984). Evaluation and Interpretation of Carcinogenesis Bioassay Results. In: Douglas, J.F. (eds) Carcinogenesis and Mutagenesis Testing. Contemporary Biomedicine, vol 4. Humana Press. https://doi.org/10.1007/978-1-4612-5164-4_10
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DOI: https://doi.org/10.1007/978-1-4612-5164-4_10
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