Abstract
Abnormal vaginal bleeding is one of the most common adolescent gynecologic problems. It is a cause of anxiety both for patient and parent. This chapter presents an orderly approach to the differential diagnosis and treatment of abnormal uterine bleeding. The importance of defining an underlying endocrinologic or hematologic abnormality as well as understanding the pathophysiology of the problem is emphasized.
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References
Wallach E: ACOG Technical Bulletin #66.September 1982
Noyes RW, Hertig AT, Rock J: Dating the endometrial biopsy. Fertil Steril 1: 8–25, 1950
Jones GS: Endocrine problems of the adolescent. Maryland State Med J 16 (7): 45–8, 1967
Kempers RD: Dysfunctional uterine bleeding. Gynecol Obstet 5 (20): 1–10, 1983
Sutherland AM: Histology of the endometrium in organic uterine “haemorrhage.”Lancet 2: 742–5, 1950
Scommegna A, Dmowski WP: Dysfunctional uterine bleeding.Clin Obstet Gynecol 16(3): 221–54, 1973
Jones GS : The luteal phase defect. Fertil Steril 27:351–6, 1976
Altcheck A : Dysfunctional uterine bleeding in adolescence. Clin Obstet Gynecol 20(3):633- 50, 1977
Vollman RF: The menstrual cycle. Major Prob Obstet Gynecol 7: 1–193, 1977
Ciaessens EA, Cowell CA: Dysfunctional uterine bleeding in the adolescent. Pediatr Clin North Am 28 (2): 369–78, 1981
Bloch B, Kort H: Thrombocytopathia as a cause of menorrhagia. Br J Obstet Gynaecol 84: 956–7, 1977
Younger JB: Testing for endocrine disorders. Female Patient 7: 17–24, 1982
Reyniak JV: Management of hypothalamic anovulation. Female Patient 7: 35–40, 1982
Drake TS, O’Brien WF, Tredway DR: Pituitary response to LH RH in hypothyroid women. Obstet Gynecol 56: 488–91, 1980
Jones GS, De Moraes-Ruehsen M: A new syndrome of amenorrhea in association with hypergonadotropism and apparently normal follicular apparatus. Am J Obstet Gynecol 104: 597–600, 1969
Sheldrake P, Cormack M: Variations in menstrual cycle symptom reporting. J Psychosom Res 20: 169–77, 1976
Osofsky HJ, Fisher S: Psychological correlates of the development of amenorrhea in a stress situation. Psychosom Med 29: 15–23, 1967
Singh KB: Menstrual disorders in college students. Am J Obstet Gynecol 140: 299–302, 1981
Stein IF,Leventhal ML: Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 29: 181–91, 1935
Vara P, Niemineva K: Small-cystic degeneration of ovaries as an incidental finding in gynecological laparotomies. Acta Obstet Gynecol Scand 31: 94–107, 1951
Twombly GH, Bassen M, Meisel D, etal: Estrogen storage in fat. Am J Obstet Gynecol 99: 785–95, 1965
Yen SS: The polycystic ovary syndrome. Clin Endocrinol (Oxf) 12: 177–207, 1980
Bates GW: When puberty begins, so do many of its disorders. Contemp Obstet Gynecol 19: 165–76, 1982
Lender M, Lawrence AM: Anorexia nervosa. Female Patient 7: 1–5, 1982
Feicht CB, Johnson TS, Marvin BJ, etal: Secondary amenorrhea in athletes. Lancet 2: 1145–6, 1978
Speroff L, Glass R, Kase N: Clinical Gynecologic Endocrinology and Infertility, 3rd ed. Baltimore, Williams & Wilkins, 1983
Frisch RE, Wyshak G, Vincent L: Delayed menarche and amenorrhea in ballet dancers. N Engl J Med 303: 17–9, 1980
Yates A, Leehey K, Shisslak CM: Running— an analogue of anorexia? N Eng J Med 308: 251–255, 1983
McArthur JW, Bullen BA, Beitins IZ, etal: Hypothalamic amenorrhea in runners of normal body composition. Obstet Gynecol Survey 36: 89–91, 1981
Friedman CI, Barrows H, Kim MH: Hypergonadotropic hypogonadism. Am J Obstet Gynecol 145: 360–72, 1983
Johnson TR,Petersen EP: Gonadotropin- induced pregnancy following “premature ovarian failure.”Fertil Steril 31: 351–2, 1979
Starup J, Pedersen H: Hormonal and ultra- structural observations in a case of resistant ovary syndrome. Acta Endocrinol 89: 744–52, 1978
Marut EL, Williams RF, Cowan BD, etal: Pulsatile pituitary gonadotropin secretion during maturation of the dominant follicle in monkeys: estrogen positive feedback enhances the biological activity of LH. Endocrinology 109: 2270–2, 1981
Caldwell DV,Luborsky-Moore JL: A functional LH agonist and LH receptor antagonist in serum from a patient with premature ovarian failure syndrome. In: Abstracts of the Endocrine Society Meeting, Miami, June 15, 1978
Starup J, Sele V: Premature ovarian failure. Acta Obstet Gynecol Scand 52: 259–68, 1973
Vallotton MB,Forbes AP: Antibodies to cytoplasm of ova. Lancet 2: 264–5, 1966
Coulam CB,Ryan RJ: Premature menopause. I. Etiology. Am J Obstet Gynecol 133: 639–43, 1979
Cramer DW, Welch WR, Cassells S, etal: Mumps, menarche, menopause, and ovarian cancer. Am J Obstet Gynecol 147: 1–6, 1983
Monroe SE, Levine L, Chang RJ, et:al: Prolactin-secreting pituitary adenomas. V. Increased gonadotroph responsitivity in hyperprolactinemic women with pituitary adenomas. J Clin Endocrinol Metab 52: 1171 - 8, 1981
Pepperell RJ:Prolactin and reproduction.Fertil Steril 35: 267–74,1981
Schlecht J, Sherman B, Halmi N, etal: Prolactin-secreting pituitary tumors. Endocrinol Rev 1: 295 - 312, 1980
Cuellar FG: Bromocriptine mesylate (Parlodel) in the management of amenorrhea/ galactorrhea associated with hyperprolactinemia. Obstet Gynecolo 55: 278–84, 1980
Archer DF, Lattanzi DR, Moore EE, et al: Bromocriptine treatment of women with suspected pituitary prolactin-secreting microadenomas. Am J Obstet Gynecol 143: 620–5, 1982
Gurpide E, Gusberg SB, Tseng, L: Estradiol binding and metabolism in human endometrial hyperplasia and adenocarcinoma. J Steroid Biochem 7: 891–6, 1976
DeVore GR, Owens O, Kase N: Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding—doubleblind randomized control study. Obstet Gynecol 59: 285–91, 1982
Anderson ABM, Haynes PJ, Guillebaud J, etal: Reduction of menstrual bloodloss by prostaglandin-synthetase inhibitors. Lancet 1: 774–6, 1976
Southam AL, Richart RM: The prognosis for adolescents with menstrual abnormalities. Am J Obstet Gynecol 94: 637–45, 1966
Glinter K: Chronic pelvic pain. J Am Osteopath Assoc 74; 335–41, 1974
Goldstein D, Decholnoky C, Leventhal J, etal: New insights into the old problem of chronic pelvic pain. J PediatrSurg 14: 675–80, 1979
Gross R, Doerr H, Caldirola D, et al: Borderline syndrome and incest in chronic pelvic pain patients. IntJ Psychiatry Med 10:79–96, 1980-81
Kleinhaus S, Hein K, Sheran M, etal: Laparoscopy for diagnosis and treatment of abdominal pain in adolescent girls. Arch Surg 112: 1178–9, 1977
Ebers G: The Papyrus Ebers, Quoted in Ridley J: The histogenesis of endometriosis: a review of facts and fancies.Obstet Gynecol Surv 23: 1–8, 1968
Henriksen E: Primary endometriosis of the urinary bladder: report of one case. JAMA 104: 1401–3, 1935
Ripstein C, Rohman M, Wallach J: Endometriosis involving the pleura. J Thorac Surg 37: 464–71, 1959
Lombardo L, Mateos J, Barroeta F: Subarachnoid hemorrhage due to endometriosis of the spinal canal. Neurology 18: 423–6, 1968
Rosenberg S, Riddick D: Successful treatment of catamenial hemoptysis with danazol. Obstet Gynecol 57: 130–2, 1981
Goldstein D, DeCholnoky C, Emans S: Adolescent endometriosis. J Adol Health Care 1: 37–41, 1980
Chapman D, Ward A: Endometriosis in adolescents. J Reprod Med 27: 156–60, 1982
Pelland P: Sterilization by laparoscopy. Clin Obstet Gynecol 26: 321–33, 1983
Phillips J, HylkaJ, Hylka B, Corson S: 1979 AAGL membership survey. J Reprod Med 26: 529–33, 1981
Muller G, Dehalleux J, Ritter J, et al: Association of genital and urinary malformation in women. Gynecol Obstet 67: 521–32, 1968
Nunley W, KitchinJ: Congenital atresia of the uterine cervix with pelvic endometriosis. Arch Surg 115: 757–8, 1980
Fallon J: Endometriosis in youth. JAMA 131: 1405–6, 1946
Von Rokitansky : Ztschrdkk Gesellsch Aertweinezu Ueberusdausen-neubildung in uterus and ovarian sarcoma. 37:577, 1860
Sampson J: The life history of ovarian hematomas of endometrial type. Am J Obstet Gynecol 4: 451, 1922
Sampson J: Intestinal adenomas of endometrial type. AMA Arch Surg 5: 217, 1922
Novak E: The significance of uterine mucosa in the fallopian tube with a discussion of the origin of aberrant endometrium. Am J Obstet 12: 484, 1926
Markee J: Menstruation in intraocular endometrial transplants in the rhesus monkey. Contrib Embyol 28: 233, 1940
TeLinde R, Scott R: Experimental endometriosis. Am J Obstet Gynecol 60: 1147–73, 1950
Heim K: Beitrag Fur Frage Verschleppung- smoglichkeit Und Wachs Turns Fähigkeit Menschlicher Uterusscheleimhaut. Zentralbl Gynaekol 51: 1818–21, 1927
Heim K: Location of endometriosis. Arch Gynaekol 152: 269, 1933
Hartman C: Regeneration of monkey uterus after surgical removal of the endometrium and accidental endometriosis. West J Surg 52: 87–102, 1944
Steck W, Helwip E: Cutaneous endometriosis. Clin Obstet Gynecol 9: 373, 1966
Szlachter N, Moskowitz J, Bigelow B, etal: Iatrogenic endometriosis substantiation of the Sampson hypothesis. Obstet Gynecol 55: 52S, 1980
Meyer R: Ueber Endometrium in Der Tube Sowie Uber Die Hieraus Ent Stehenden Wirklichen Un Vermeintlichen Folgen. Zentralbl Gynaekol 51: 1482–91, 1927
Schifrin B, Erez S, Moore J, Teenage endometriosis. Am J Obstet Gynecol 116: 973–80, 1973
Derryberry W, Bonney W: Pelvic endometriosis in a 15 year old. Obstet Gynecol 27: 558–61, 1968
Bullock J, Massey F, Gambrell R: Symptomatic endometriosis in teenagers. A reappraisal. Obstet Gynecol 43: 896–900, 1974
Meigs J: Endometriosis—its significance. Ann Surg 114: 866–74, 1941
Hanton E, Malkasian G, Dockerty M, etal: Endometriosis in young women. Am J Obstet Gynecol 98: 116–20, 1967
Hanton E, Malkasian G, Dockerty M, etal: Case report. Endometriosis associated with complete or partial obstruction of menstrual egress. Obstet Gynecol 28: 626–9, 1966
>Moore J, Schifrin B, Erez S: Ovarian tumors in infancy, childhood, and adolescence. Am J Obstet Gynecol 99: 913–22, 1967
Brüser N: The common occurrence of endometriosis in young women. Can Med Assoc J 72: 190–4, 1955
Depp O, Pope D: Early conservative surgery in endometriosis. South Med J 49: 1345–55, 1956
TeLinde R: Endometriosis.Clin Obstet Gynecol 4: 788–806, 1961
Sutton L: The clinical features of endometriosis. NY J Med 41: 1343–51, 1941
Sutton L: Etiologic factors in endometriosis with report of a case with reflux menstruation. NC Med J 31: 45–7, 1970
McDonald R. Uterus didelphys with endometriosis. Am J Obstet Gynecol 4 5: 1038 - 41, 1943
Mittal G, Choudhury T, Cortez J: Endometriosis of the appendix presenting as acute appendicitis. Am J Surg 142: 519–21, 1981
King W: Metastatic endometriosis and abdominal scars. Can J Surg 22: 579, 1979
Simpson J, Elias S, Malinak R, et al. Here- ditable aspects of endometriosis. I. Genetic studies. J Obstet Gynecol 37: 327–31, 1981
Selensky T, Liu D: Endometriosis associations with menorrhagia. Infertility and oral contra¬ceptives. Int J. Gynaecol Obstet 17: 573–6, 1978
Brosens I, Koninckx P, Corveleyn P: A study of plasma progesterone, estradiol-17B, prolactin, and LH levels and the luteal phase appearance of ovaries in patients with endometriosis and infertility. Br J Obstet Gynaecol 85: 246–50, 1978
Kistner R: Current status of the hormonal therapy of endometriosis. Clin Obstet Gynecol 9: 271–92, 1966
Cradick R: The nonsurgical treatment of endometriosis: a preliminary report on the use of methyltestosterone. NC Med J 11:56— 7, 1950
McArthur J, Ulfelder A: The effect of pregnancy on endometriosis. Obstet Gynecol Survey 20: 709–25, 1965
Meigs J: Endometriosis: Etiologic role of marriage, age, and parity: conservative treat¬ment. Obstet Gynecol 7: 46–53, 1953
TeLinde R: In: Counsellor vs. Crenshaw. Clinical and surgical review of endometriosis. Am J Obstet Gynecol 62:930–42, 1951
Willman E, Collins W, Clayton S: Studies in the involvement of prostaglandins in uterine symptomatology and pathology. Br J Obstet Gynaecol 83: 337–41, 1976
Meldrum D, Shamonki J, Clark K, etal: Prostaglandin content of ascitic fluid in endometriosis: a preliminary report presented at the 25th Annual Meeting of the Pacific Coast Fertility Society, October 1977, Palm Springs, California
Shenken R, Asch R: Surgical induction of endometriosis in the rabbit: effects on fertility and concentrations of peritoneal fluid prostaglandin. Fertil Steril 34: 581 - 7, 1980
Drake T, O’Brien N, Ramwell P, etal: Peritoneal fluid thromboxane B2 and 6-keto- prostaglandin Fla in endometriosis. Am J Obstet Gynecol 140: 401–4, 1981
Badawy S, Marshall L, Gabal A, etal: The concentration of 13,14-di-hydro - 15-keto prostaglandin F2a and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril 38: 166–70, 1982
Haney A, Muscato J, Weinberg J: Peritoneal fluid cell populations in infertility patients. Fertil Steril 35: 696–8, 1981
Dmowski W, Cohen M: Treatment of endo¬metriosis with an antigonadotropin danazol: A laparoscopic and histologic evaluation. Obstet Gynecol 46: 147–54, 1975
Dmowski W, Cohen M: Antigonadotropin (danazol) in the treatment of endometriosis. Am J Obstet Gynecol 130: 41–7, 1978
Acosta A, Buttram V, Vesch P, etal: A proposed classification of endometriosis. Obstet Gynecol 42: 19–25, 1973
American Fertility Society : Classification of endometriosis, Fertil Steril 32:633–4, 1979
Braun P, Wildt L, Leyendecker G: The effect of danazol on gonadotropin secretion during the folllicular phase of the menstrual cycle. Fertil Steril 40: 37–44, 1983
Wood G, Wu C, Flickinger G, et al: Hormonal changes associated with danazol therapy. Obstet Gynecol 45: 302–4, 1975
Barbieri R, Ryan K: Danazol: endocrine pharmacology and therapeutic applications. Am J Obstet Gynecol 141: 453–63, 1981
Asch R, Fernandez E, Smith C, et al: Effects of danazol on gonadotropin levels in castrated rhesus monkeys. Obstet Gynecol 53: 415–21, 1979
Schneider H: Changes of prolactin secretion following long-term danazol application. Fertil Steril 36: 725–8, 1981
Sherins R, Paulsen C: Pituitary and testicular function studies. I. Experience with a new gonadal inhibitor, 17a-pregn-4-en-20-yno [2,3-d]isoxazol-17-ol (danazol). J Clin Endo¬crinol Metab 32: 522–31, 1971
Stillman R, Fencl MDeM, Schiff I, etal: Inhibition of adrenal steroidogensis by danazol in vivo. Fertil Steril 33: 401–6, 1980
Asch R, Fernandez E, Siler-Khodr T, etal: Mechanism of induction of luteal phase defects by danazol. Am J Obstet Gynecol 136: 932–7, 1980
Nilsson B, Sodergard R, Damber M, et al: Danazol and gestagen displacement of testos¬terone. An influence on sex hormone binding globulin binding capacity. Fertil Steril 38: 48–53, 1982
Barbieri R, Canick J, Makris A, et al: Danazol inhibits steroidogenesis. Fertil Steril 28:809–13, 1977
Meldrum D, Pardridge W, Karow W, etal: Hormonal effects of danazol and medical oophorectomy in endometriosis. Obstet Gynecol 62: 480–5, 1983
Panal A, Maas D: Danazol and thyroid function tests. Lancet 1: 102–3, 1977
Laureil C, Rinnevik G: Comparison of plasma protein changes induced by danazol in pregnancy. Postgrad Med J 55 (Suppl 5): 40–3, 1979
Luciano K, Hauser K, Chapler F, et al: Effects of danazol on plasma lipid and lipoprotein levels in healthy women and in women with endometriosis. Am J Obstet Gynecol 145: 422–32, 1983
Barbieri R, Lee H, Ryan K: Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity. Fertil Steril 31: 182–5, 1979
Musich J, Behrman S, Menon K: Estrogenic and antiestrogenic effects of danazol administration in studies of estrogen receptor binding. Am J Obstet Gynecol 140: 62–7, 1981
Sanfilippo J, Teichman J, Melvin J, etal: Influence of danazol on cytoplasmic and nuclear estrogen binding capacity in the uterus. Am J Obstet Gynecol 147: 364 - 8, 1983
Jenkin G, Cookson C, Th orb urn G: The interaction of human endometrial and myo- metrial steroid receptors with danazol. Clin Endocrinol 19: 377–88, 1983
Dmowski W, Kapetanakis E, Scommegna A: Variable effects of danazol on endometriosis at 4 low-dose levels. Obstet Gynecol 59: 408–15, 1982
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Sanfilippo, J.S., Yussman, M.A. (1985). Gynecologic Problems of Adolescence. In: Lavery, J.P., Sanfilippo, J.S. (eds) Pediatric and Adolescent Obstetrics and Gynecology. Clinical Perspective in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5064-7_6
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DOI: https://doi.org/10.1007/978-1-4612-5064-7_6
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