Abstract
The concept of puberty as a threshold event at which time a switch turns on hormonal secretion resulting in the onset of maturation of sexual and reproductive function is no longer tenable. Hormonal secretion is not negligible until the age of puberty. It is apparent that there is a dramatic, dynamic ongoing maturational process involving a changing equilibrium between simulatory and inhibitory factors regulating development which is appropriate for age throughout childhood.1–3 The net influences responsible for this change primarily reside within the central nervous system (CNS). These are expressed by intermittent gonadotropin releasing hormone (GNRH) secretion resulting in intermittent luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion, which in turn stimulate gonadal secretion.
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References
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Lee, P.A. (1985). Neuroendocrine Maturation. In: Lavery, J.P., Sanfilippo, J.S. (eds) Pediatric and Adolescent Obstetrics and Gynecology. Clinical Perspective in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5064-7_2
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