Summary
A long-term double-blind comparison between Hydergine, 4.5 mg per day and placebo, including 148 healthy pensioners of both sexes, was analyzed after 3 years of study. Based on medical and psychological assessment criteria, 52 subjects were considered to have successfully aged, and 45 to have poorly aged over this time span. The remaining subjects had either withdrawn from the study or could not be allocated to one of the two groups. A retrospective analysis of possible predictor variables yielded two statistically significant and meaningful predictors: a diagnosis of hypertension at baseline, and treatment with Hydergine. Hypertensive subjects were less likely to age with success, while treatment with Hydergine was found to be significantly associated with successful aging in our sample. The study is still ongoing.
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References
Busse, E.W., and Maddox, G.L.: Final Report—The Duke Longitudinal Studies, an Integrated Investigation of Aging & the Aged, 1955–1980. Durham, N.C.: Center for the Study of Aging and Human Development, 1980.
Colandrea, M.A., Friedman, G.D., Nichaman, M.Z., and Lynd, C.N.: Systolic hypertension in the elderly. Circulation 41, 239–245 (1970).
Jarvik, L.F.: Thoughts on the psychobiology of aging. Am. Psychol. 30, 576–583 (1975).
Kannel, W.B., Sorlie, P., Castelli, W.P., and McGee, D.: Blood pressure and survival after myocardial infarction: The Framingham study. Am. J. Card. 45, 326–330 (1980).
Larson, R.: Thirty years of research on the subjective well-being of older Americans. J. Gerontol. 33, 109–125 (1978).
Lazarus, R.S., and DeLongis, A.: Psychological stress and coping in aging. Am. Psychol. 38, 245–254 (1983).
Lehr, U.: Die Vorbereitung auf das Alter—nicht nur ein medizinisches Problem. Triangel 16, 93–103 (1977).
Palmore, E. (Ed.): Normal Aging. Durham, N.C.: Duke University Press, 1970.
Palmore, E. (Ed.): Normal Aging II. Durham, N.C.: Duke University Press, 1974.
Siegler, I.C., and Botwinick, J.: A long-term longitudinal study of intellectual ability of older adults: The matter of selective subject attrition. J. Gerontol. 34, 242–245 (1979).
Spiegel, R., Huber, F., and Koberle, S.: A controlled long-term study with ergoloid mesylates (Hydergine) in healthy, elderly volunteers: Results after three years. J. Am. Ger. Soc. 31, 549–555 (1983).
Thomae, H.: Patterns of Aging: Findings from the Bonn Longitudinal Study of Aging. Basel: Karger, 1976.
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© 1985 Springer-Verlag New York Inc.
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Spiegel, R., Köberle, S., Huber, F. (1985). Determinants of Successful Aging: Findings from a Study with Ergoloid Mesylates (Hydergine). In: Gaitz, C.M., Samorajski, T. (eds) Aging 2000: Our Health Care Destiny. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5058-6_32
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DOI: https://doi.org/10.1007/978-1-4612-5058-6_32
Publisher Name: Springer, New York, NY
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