Gene Organization and Recombination Hot Spots in the Murine Major Histocompatibility Complex

  • Michael Steinmetz
Part of the Experimental Biology and Medicine book series (EBAM, volume 13)


The major histocompatibility complex, located on chromosome 17 in the mouse, is an enormous genetic region coding for heterodimeric cell surface molecules involved in antigen recognition by T cells (for recent reviews see refs. 1–5). Five different MHC molecules have been identified in the BALB/c mouse which present antigens to T cells: The class I molecules, K, D and L, serve as recognition elements for most cytotoxic T cells, whereas the class II molecules, I-A and I-E, are guidance molecules for most helper T cells. Alpha and beta chains of class II molecules are encoded in the MHC, while for class I molecules only the α chain is. The β chain, called β2-microglobulin, is encoded by a gene located on chromosome 2.


Recombination Event Antigen Recognition Laboratory Mouse Strain Murine Major Histocompatibility Complex Thymus Leukemia 
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  1. 1.
    Klein, J., Figueroa, F. and Nagy, Z.A. Ann. Rev. Immunol. 1, 119–142 (1983).CrossRefGoogle Scholar
  2. 2.
    Steinmetz, M. and Hood, L. Science 222, 727–733 (1983).PubMedCrossRefGoogle Scholar
  3. 3.
    Schwartz, R.H. Ann. Rev. Immunol. 3, 237–261 (1985).CrossRefGoogle Scholar
  4. 4.
    Steinmetz, M. in Genetic Engineering Vol. 5 (ed. Rigby, P.W.J.) Academic Press, London, in press.Google Scholar
  5. 5.
    Mengle-Gaw, L. and McDevitt, H.O. Ann. Rev. Immunol. 3, 3657–396 (1985).CrossRefGoogle Scholar
  6. 6.
    Larhammar, D., Hammerling, U., Rask, L. and Peterson, P.A. J. Biol. Chem., in press.Google Scholar
  7. 7.
    Braunstein, N. and Germain, R. in Advances in Gene Technology: Molecular Biology of the Immune System (eds. Streilein, J.W. et al.) 119–120 (Cambridge University Press, Cambridge, 1985).Google Scholar
  8. 8.
    Widera, G. and Flavell, R.A. Proc. Natl. Acad. Sci. USA, in press.Google Scholar
  9. 9.
    Hayes, C.E. and Bach, F.H. J. Exp. Med. 151, 481–485 (1980).PubMedCrossRefGoogle Scholar
  10. 10.
    Murphy, D.B. in The Role of the Major Histocompatibility Complex in Immunology (ed. Dorf, M.E.) 1–32 (Garland STPM, New York, 1981).Google Scholar
  11. 11.
    Steinmetz, M. et al. Nature 300, 35–42 (1982).PubMedCrossRefGoogle Scholar
  12. 12.
    Kronenberg, M. et al. Proc. Natl. Acad. Sci. USA 80, 5704–5708 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    Kobori, J., Winoto, A., McNicholas, J. and Hood, L. J. Mol. Cell. Immunol. 1, 125–131 (1984).PubMedGoogle Scholar
  14. 14.
    Steinmetz, M., Stephan, D. and Fischer-Lindahl, K. Manuscript in preparation.Google Scholar
  15. 15.
    Monaco, J.J. and McDevitt, H.O. Proc. Natl. Acad. Sci. USA 79, 3001–3005 (1982).PubMedCrossRefGoogle Scholar
  16. 16.
    Chaplin, D.D. et al. Proc. Natl. Acad. Sci. USA 80, 6947–6951 (1983).PubMedCrossRefGoogle Scholar
  17. 17.
    White, P.C. et al. Nature 312, 465–467 (1984).PubMedCrossRefGoogle Scholar
  18. 18.
    Amor, M., Tosi, M., Duponchel, C., Steinmetz, M. and Meo, T. Proc. Natl. Acad. Sci. USA J32, 4453–4457 (1985).CrossRefGoogle Scholar
  19. 19.
    Carroll, M.C., Campbell, R.D., Bentley, D.R. and Porter, R.R. Nature 307, 237–241 (1984).PubMedCrossRefGoogle Scholar
  20. 20.
    White, P.C. et al. Proc. Natl. Acad. Sci. USA 82, 1089–1093 (1985).PubMedCrossRefGoogle Scholar
  21. 21.
    Steinmetz, M. et al. Unpublished results.Google Scholar
  22. 22.
    Sun, H., Goodenow, R.S. and Hood, L. J. Exp. Med., in press.Google Scholar
  23. 23.
    Weiss, E.H. et al. Nature 310, 650–655 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    Fisher, D.A., Hunt III, S.W. and Hood, L.E. J. Exp. Med. 162, 528–545 (1985).PubMedCrossRefGoogle Scholar
  25. 25.
    Snell, G.D., Dausset, J. and Nathenson, S. Histocompatibility (Academic Press, New York, 1976).Google Scholar
  26. 26.
    Sachs, D.H., Arn, J.S. and Hansen, T. J. Immunol. 123, 1965–1969 (1979).PubMedGoogle Scholar
  27. 27.
    Shiroishi, T., Sagai, T. and Moriwaki, K. Nature 300, 370–372 (1982).PubMedCrossRefGoogle Scholar
  28. 28.
    Saito, H., Maki, R.A., Clayton, L.K. and Tonegawa, S. Proc. Natl. Acad. Sci. USA 80, 5520–5524 (1983).PubMedCrossRefGoogle Scholar
  29. 29.
    Jeffreys, A.J., Wilson, V. and Thein, S.L. Nature 314, 67–73 (1985).PubMedCrossRefGoogle Scholar
  30. 30.
    Bodmer, J. and Bodmer, W. Immunol. Today 5, 251–254 (1984).CrossRefGoogle Scholar
  31. 31.
    Mellor, A.L., Antoniou, J. and Robinson, P.J. Proc. Natl. Acad. Sci. USA, in press.Google Scholar
  32. 32.
    Klein, J., Figueroa, F. and David, C.S. Immunogenetics 17, 553–596 (1983).PubMedCrossRefGoogle Scholar
  33. 33.
    Savarirayan, S., Lafuse, W.P. and David, C.S. Transplant. Proc. 17, 702–706 (1985).Google Scholar

Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Michael Steinmetz
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

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