Class III HLA Genes and Systemic Lupus Erythematosus
The well known HLA/disease associations have often in the past been attributed to the effects of Class 1 or 11 MHC products on an individual’s immune responsiveness. However there are reasons for thinking that more than one mechanism may be responsible for these associations. In this paper, we will outline the evidence which leads us to conclude that the Class 111 genes, encoding polymorphisms for the complement system proteins of C4A, C4B, and C2 govern susceptibility to systemic lupus erythematosus (SLE).
KeywordsSystemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Null Allele Classical Pathway Slow Acetylator
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