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Class III HLA Genes and Systemic Lupus Erythematosus

  • J. R. Batchelor
  • A. H. L. Fielder
  • S. Hing
  • I. A. Dodi
  • C. Speirs
  • G. R. V. Hughes
  • R. Bernstein
  • P. Malasit
  • D. A. Isenberg
  • M. Snaith
  • H. Chapel
  • E. Sim
Part of the Experimental Biology and Medicine book series (EBAM, volume 13)

Abstract

The well known HLA/disease associations have often in the past been attributed to the effects of Class 1 or 11 MHC products on an individual’s immune responsiveness. However there are reasons for thinking that more than one mechanism may be responsible for these associations. In this paper, we will outline the evidence which leads us to conclude that the Class 111 genes, encoding polymorphisms for the complement system proteins of C4A, C4B, and C2 govern susceptibility to systemic lupus erythematosus (SLE).

Keywords

Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Null Allele Classical Pathway Slow Acetylator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • J. R. Batchelor
    • 1
  • A. H. L. Fielder
    • 1
  • S. Hing
    • 1
  • I. A. Dodi
    • 1
  • C. Speirs
    • 2
  • G. R. V. Hughes
    • 3
  • R. Bernstein
    • 3
  • P. Malasit
    • 4
  • D. A. Isenberg
    • 5
  • M. Snaith
    • 5
  • H. Chapel
    • 6
  • E. Sim
    • 7
  1. 1.Department of Immunology, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK
  2. 2.Department of Clinical Pharmacology, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK
  3. 3.Rheumatology Unit, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK
  4. 4.Renal Unit, Faculty of Medicine, Siriraj HospitalMahidol UniversityBangkok 7Thailand
  5. 5.Department of RheumatologyUniversity College HospitalLondonUK
  6. 6.Department of Clinical ImmunologyJohn Radcliffe HospitalHeadington, OxfordUK
  7. 7.Department of PharmacologyJohn Radcliffe HospitalHeadington, OxfordUK

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