Organisation and Expression of Human T Cell Receptor Genes

  • M. J. Owen
  • M. K. L. Collins
  • A.-M. Kissonerghis
  • M. J. Dunne
  • S. John
Part of the Experimental Biology and Medicine book series (EBAM, volume 13)


The T cell antigen receptor has been defined as a disulphide-linked heterodimer (Ti) comprising an α and a β chainl1–3. A variety of lines of evidence indicate that the Ti molecule confers antigen and MHC binding specificity to a T cell (see, for example, ref. 4). However, it is clear that other surface molecules are also involved in T cell activation in response to antigen. Most notable amongst these is the T3 glycoprotein which is apparently physically associated with Ti at the cell surface2, 4–6. The expression of T3 and Ti at the cell surface is most probably obligatory6, 7.


Lymphoma Electrophoresis Polypeptide Polyacrylamide Isobe 


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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • M. J. Owen
    • 1
  • M. K. L. Collins
    • 1
  • A.-M. Kissonerghis
    • 1
  • M. J. Dunne
    • 1
  • S. John
    • 1
  1. 1.Imperial Cancer Research Fund, Tumour Immunology Unit, Dept. of ZoologyUniversity College LondonLondonUK

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