Organisation and Expression of Human T Cell Receptor Genes
The T cell antigen receptor has been defined as a disulphide-linked heterodimer (Ti) comprising an α and a β chainl1–3. A variety of lines of evidence indicate that the Ti molecule confers antigen and MHC binding specificity to a T cell (see, for example, ref. 4). However, it is clear that other surface molecules are also involved in T cell activation in response to antigen. Most notable amongst these is the T3 glycoprotein which is apparently physically associated with Ti at the cell surface2, 4–6. The expression of T3 and Ti at the cell surface is most probably obligatory6, 7.
KeywordsLymphoma Electrophoresis Polypeptide Polyacrylamide Isobe
Unable to display preview. Download preview PDF.