Abstract
The intimate relationship between Ia antigens and immune responsiveness to a multitude of natural and synthetic antigens has been known for some time (1, 2). Recent studies using either anti-Ia antisera or monoclonal antibodies to block immune responses strongly suggest that la antigens are the products of Ir genes (3–5), but how a limited number of Ia antigens differentially regulate responses to a myriad of antigens is yet to be resolved. Presumably, their role in the presentation of antigen to immunocompetent cells is of fundamental importance and, as with other systems, Ia:antigen interactions will surely be dictated by the structures of the individual components of the la:antigen complex on the surface of the antigen-presenting cell. Primary structural alterations in the alpha and beta chains of the Class II heterodimer likely result in a failure to present antigen in a configuration appropriate for recognition and thus the failure of an animal to mount an immune response to that antigen. These alterations must also account for the multiple allelic variations recognized by both antibodies and T-cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Mevitt, H.O. J. Immunogenetics 8:287–295 (1981).
Klein, J., Juretic, A., Baxevanis, C. and Nagy, Z. Nature 291:455–460 (1981).
Berzofsky, J.A. and Richman, L.K. J. Immunol. 126:1898 (1981).
Steinman, L., Rosenbaum, J.T., Sriram, S. and Mevitt, H.O. Proc. Natl. Acad. Sci. USA 78:7111–7114 (1981).
Adelman, N.E., Watling, D.L. and Mevitt, H.O. J. Exp. Med. 158:135–1355 (1983).
Benoist, C.O., Mathis, D.J., Kanter, M.R., Williams, V.E. and Mevitt, H.O. Proc. Natl. Acad. Sci. USA 80, 534–538 (1983).
Landais, D., Matthes, H., Benoist, C. and Mathis, D. Proc. Natl. Acad Sci. USA 82, 2930–2934 (1985)
Biggin, M.D., Gibson, T.J. and Hong, G.F. Proc. Natl. Acad. Sci. USA 80, 3963–3965 (1983).
Choi, E., Mclntyre, K., Germain, R.N. and Seidman, J.G. Sci. 221:283–286 (1983).
Malissen, M., Hunkapiller, T. and Hood, L. Science 221, 750–754 (1983).
Larhammar, D., Hammerling, D., Denaro, M., Lind, T., Flavell, R.A., Rask, L. and Peterson, P.A. Cell 34, 179–188 (1983).
Estess, P., Begovich, A.B., Koo, M., Jones, P.P. and Mevitt, H.O. manuscript in preparation.
Mengle-Gaw, L. and Mevitt, H.O. Proc. Natl. Acad. Sci. USA 80, 7621–7625 (1983).
Saito, H., Maki, R.A., Clayton, L.K., and Tonegawa, S. Proc. Natl. Acad. Sci. USA 80, 5520–5524 (1983).
Mengle-Gaw, L. and Mevitt, H.O. Proc. Natl. Acad. Sci. USA 82, 2910–2914 (1985).
Bell, J.I., Estess, P., St. John, T., Saiki, R., Watling, D.L., Erlich, H.A. and Mevitt, H.S. Proc. Natl. Acad. Sci. USA 82, 3405–3409 (1985).
Gustafsson, K., Wiman, K., Emmoth, E., Larhammar, D., Böhme, J., Hyldig-Nielsen, J.J., Rönne, H., Petterson, P. and Rask, L. EMBO J. 3, 1655–1661 (1984).
Mclntyre, K.R. and Seidman, J.G. Nature 308, 551–553 (1984).
Mengle-Gaw, L., Conner, S., Mevitt, H.O. and Fathman, C.G. J. Exp. Med. 160, 1184–1194 (1984).
Klein, J. Biology of the Mouse Histocompatibility-2 Complex, Springer-Verlag, N.Y. (1975).
Wu, T.T. and Kabat, E.A. J. Exp. Med. 132, 211–250 (1970).
Kappler, J.W., Skidmore, B., White, J. and Marrack, P. J. Exp. Med. 153, 1198–1214 (1981).
Freiinger, J.G., Shigeta, M., Infante, 7A.J., Nelson, P.A., Pierres, and Fathman, C.G. J. Exp. Med. 159, 704–715 (1984).
P. Jones, pers. comm.
Kupinski, J.M., Plunkett, M.C., Freed, J.H. J. Immunol. 130, 2277–2280 (1983).
Pierres, M., Devaux, C., Dossito, M. and Marchetto, S. Immunogenetics 14, 481–495 (1981).
Klein, J., Figueroa, F. and David, C.S. Immunogenetics 17, 553–596 (1983).
Mevitt, H.O., Deak, B.D., Shreffler, D.C., Klein, J. Stimpfling, J.H. and Snell, G.D. J. Exp. Med. 135, 1259–1278 (1972).
Mevitt, H.O. Chinitz, A. Science 163, 1207–1208 (1969).
Grumet, F.C. and Mevitt, H.O. Transplantation 13, 171–173 (1972).
Markman, M. and Dickler, H.B. J. Immunol. 124, 2909–2911 (1980).
Lonai, P., Murphy, D.B. and Mevitt, in Ir Genes and Ia Antigens, Academic Press, Inc., S.F. (1978).
Deak, B.D., Meruelo, D. and Mevitt, H.O. J. Exp. Med. 147, 599–604 (1978).
Pettinelli, C.B., Fritz, R.B., Chou, C.H-J. and Marlin, D.E. J. Immunol. 129, 1209–1211 (1982).
Fritz, R.B., Chou, C. H-J. and Marlin, D.E. J. Immunol. 130, 191–194 (1983).
Fritz, R.B., Perry, L.L. and Chou, C.H-J. Prog. Clin. Biol. Res. 146, 235- (1984).
Fritz, R.B., Skeen, M.J., Chou, C.H-J., Garcia, M.L. and Egorov, I.K. J. Immunol 134, 2328–2332 (1985).
Trotter, J., Sriram, S., Rassenti, L., Chou, C.H- J., Fritz, R. and Steinman, L. J. Immunol 134, 2322–2327 (1985).
Zamvil, S.S. Nelson, P.A., Mitchell, D.J., Knobler, R.L., Fritz, R.B. and Steinman, L. J. Exp. Med, in press (1985).
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1986 The Humana Press Inc.
About this chapter
Cite this chapter
Estess, P., Begovich, A.B., Jones, P.P., McDevitt, H.O. (1986). Structure/Function Relationships Among Murine Class II Molecules: Sequence Analysis of I-A cDNA Clones. In: Feldmann, M., McMichael, A. (eds) Regulation of Immune Gene Expression. Experimental Biology and Medicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-5014-2_1
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5014-2_1
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9399-6
Online ISBN: 978-1-4612-5014-2
eBook Packages: Springer Book Archive