Biological Consequences of S-Adenosyl-L-Homocys-Teinase Inhibition by Acyclic Adenosine Analogs

  • A. Holý
  • I. Votruba
  • A. Merta
  • E. DeClercq
  • R. Jelínek
  • K. Sláma
  • K. Beneš
  • O. Melichar
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 12)

Abstract

S-Adenosyl-L-homocyteinase (SAH-hydrolase) is recognized as an important enzyme in the regulation of biological transmethylations mediated by methyl transferases. Thus, the inhibitors of this enzyme can be expected to evoke a multitude of biological effects. The numerous examples of such activities have been reviewed recently (Ueland, 1982).

Keywords

Adenosine Adenine Nucleoside Crest Hydrolase 

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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • A. Holý
    • 1
  • I. Votruba
    • 1
  • A. Merta
    • 1
  • E. DeClercq
    • 5
  • R. Jelínek
    • 2
  • K. Sláma
    • 3
  • K. Beneš
    • 4
  • O. Melichar
    • 1
  1. 1.Inst.Org.Chenu Biochem.PrahaCzech Republic
  2. 2.Inst.Exp.Med.PrahaCzech Republic
  3. 3.Inst.Entomol.PrahaCzech Republic
  4. 4.Inst.Exp.BotanyPrahaCzech Republic
  5. 5.Rega InstituutLeuvenBelgium

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