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Biological Consequences of S-Adenosyl-L-Homocys-Teinase Inhibition by Acyclic Adenosine Analogs

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Biological Methylation and Drug Design

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 12))

Abstract

S-Adenosyl-L-homocyteinase (SAH-hydrolase) is recognized as an important enzyme in the regulation of biological transmethylations mediated by methyl transferases. Thus, the inhibitors of this enzyme can be expected to evoke a multitude of biological effects. The numerous examples of such activities have been reviewed recently (Ueland, 1982).

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References

  • Beneš,K., Holý,A. and Melichar,O. (1984) Biol. plant. 26, 144–150.

    Article  Google Scholar 

  • DeClercq, E. and Holý,A. (1979) J.Med.Chem. 22, 510.

    Article  CAS  Google Scholar 

  • DeClercq,E., Leyten,R., Sobis,H., Matoušek,J., Holý.A. and DeSomer,P. (1981) Toxic.Appl.Pharmacol. 59, 441–451.

    Article  CAS  Google Scholar 

  • DeClercq,E., Bergstrom,D.E., Holý,A. and Montgomery,J.A. (1984) Antiviral Res. 4, 119–133.

    Article  CAS  Google Scholar 

  • DeClercq,E. and Holý,A. (1985) J.Med.Chem.28, 282–287.

    Article  CAS  Google Scholar 

  • Dragúň,M., Rada,B. and Holý, A. (1983) Acta Virol. 27, 119–129.

    PubMed  Google Scholar 

  • Gelbič,I., Tonner,M. and Holý,A. (1984) Acta ent.bohemoslov. 81, 46–53.

    Google Scholar 

  • Gomi,T., Ishiguro,Y. and Fujioka,M. (1985) J.Biol.Chem. 260, 2789–2793.

    PubMed  CAS  Google Scholar 

  • Holý,A., Votruba,I. and DeClercq,E. (1985a) Collect.Czech.Chem.Commun. 50, 245–261.

    Article  Google Scholar 

  • Holý,A., Votruba,I. and DeClercq,E. (1985b) Collect.Czech.Chem.Commun. 50, 262–279.

    Article  Google Scholar 

  • Holý,A., Kohoutová, J., Merta,A. and Votruba,I. (1985c) Collect.Czech.Chem.Commun., in press.

    Google Scholar 

  • Jelínek,R., Holý,A. and Votruba,I. (1981) Teratology. 24, 267–275.

    Article  PubMed  Google Scholar 

  • Jelínek,R., Doskočil.M. and Holý,A. (1985) Teratogenesis, Carcinogenesis, Mutagenesis, in press

    Google Scholar 

  • Merta,A. Votruba,I., Veselý,J. and Holý,A. (1983) Collect.Czech.Chem.Commun. 48, 2701.

    Article  CAS  Google Scholar 

  • Schanche,J.S., Schanche,T., Ueland,P.M., Holý,A. and Votruba,I. (1984) Molec.Pharmacol. 26, 553–558.

    CAS  Google Scholar 

  • Sláma,K., Holý,A. and Votruba, I. (1983) Ent.exp.appl. 33, 9–14.

    Article  Google Scholar 

  • Šebestová,L., Votruba,I. and Holý,A. (1984) Collect.Czech.Chem.Commun. 49, 1543–1551.

    Article  Google Scholar 

  • Ueland,P.M., Skotland,T., Døskeland,S.O. and Flatmark,T. (1978) Biochim.Biophys.Acta. 553, 57–65.

    Google Scholar 

  • Ueland,P.M. (1982) Pharmacol.Revs. 34, 223–253.

    CAS  Google Scholar 

  • Votruba,I. and Holý,A. (1980) Collect.Czech.Chem. Commun. 45, 3039–3044.

    CAS  Google Scholar 

  • Votruba,I. and Holý,A. (1982) Collect.Czech.Chem. Commun. 47, 167–172.

    Article  CAS  Google Scholar 

  • Votruba, I., Holý,A. and Rosenberg,I. (1983a) Collect.Czech.Chem.Commun. 48, 2549–2557.

    Article  CAS  Google Scholar 

  • Votruba,I., Holý,A. and DeClercq,E. (1983b) Acta Virol. 27, 273–276.

    PubMed  CAS  Google Scholar 

  • Votruba.I., Holý,A., Rosenberg,I. and Sláma,K. (1985) Insect Biochem., in press.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Inst.Org.Chenu Biochem., Praha, Czech Republic

    A. Holý, I. Votruba, A. Merta & O. Melichar

  2. Inst.Exp.Med., Praha, Czech Republic

    R. Jelínek

  3. Inst.Entomol., Praha, Czech Republic

    K. Sláma

  4. Inst.Exp.Botany, Praha, Czechoslovakia, Czech Republic

    K. Beneš

  5. Rega Instituut, Leuven, Belgium

    E. DeClercq

Authors
  1. A. Holý
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  2. I. Votruba
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  3. A. Merta
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  4. E. DeClercq
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  5. R. Jelínek
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  6. K. Sláma
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  7. K. Beneš
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  8. O. Melichar
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Editor information

Editors and Affiliations

  1. Pharmaceutical Chemistry Department, The University of Kansas, Lawrence, Kansas, USA

    Ronald T. Borchardt

  2. NIADDK, National Institutes of Health, Bethesda, Maryland, USA

    Cyrus R. Creveling

  3. Department of Pharmacology, University of Bergen, Bergen, Norway

    Per Magne Ueland

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© 1986 The Humana Press Inc.

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Holý, A. et al. (1986). Biological Consequences of S-Adenosyl-L-Homocys-Teinase Inhibition by Acyclic Adenosine Analogs. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_33

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  • DOI: https://doi.org/10.1007/978-1-4612-5012-8_33

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9398-9

  • Online ISBN: 978-1-4612-5012-8

  • eBook Packages: Springer Book Archive

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