Abstract
S-Adenosyl-Methionine (SAMe), the universal methyl donor in methylation reactions, has been extensively studied over the past twenty Years in a variety of neuropsychiatric conditions (Agnoli et al., 1976; Fazio et al., 1974; Carney et al., 1983). Following early case reports indicating that SAMe might have a mood-elevating effect, studies were conducted in Italy (Agnoli et al., 1976; Del Vecchio et al., 1978; Miccoli et al., 1978; Muscettola et al., 1982; Salvadorini et al., 1980), Germany (Kufferle et al., 1982) and in the United States (Lipinski et al., 1984); these provide evidence that parenterally administered SAMe can produce clinical improvement in depressed patients. In comparison to standard antidepressants, SAMe is claimed to be as effective as the tricyclics while producing fewer side effects.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Agnoli, A., Andreoli, V., Casacchia, M. and Cerbo, R. (1976) Effect of S-adenosy1-L-methionine (SAMe) upon depressive symptoms.J. Psychiatr. Res. 13, 43.
Agnoli, A., Andreoli, V., Casacchia, M., Maffei, F. and Fazio, C. (1978) in Transmethylations and the Central Nervous System (Andreoli, V., Agnoli, A. and Fazio, C., Eds.) p. 170. Springer-Verlag, Mew York.
Algeri, S., Catto, E. and Curcio, M. (1979) in Biochemical and Pharmacological Roles of Adenosylmethionine in the Central Nervous System (Zappia, V. and Usdin, E., Eds.) Pergamon Press, London.
Baldessarini, R.J., Stramentinoli, G. and Lipinski, J.F. (1979) Methylation hypothesis. Arch. Gen. Psychiatry, 36, 303.
Carney, M.W.P., Martin, R., Bottigheny, T., Reynolds, E.H., Nissenbaum, H., Toone, B.K. and Sheffield, B.F. (1983) Switch mechanism in affective illness and S-adenosy1-methionine. Lancet, 1, 820.
Carruthers, S.G., Ghosal, A., McDevitt, D.G., Nelson, J.K. and Shanks, R.G. (1974) The assessment of beta-adrenoceptor blocking drugs in hyperthyroidism. Br. J. Clin. Pharmacol. 1, 93.
Cohen, R.M., Campbell, I.C. and Yamaguchi, I. (1982) Cardiovascular changes in response to selective monoamine oxidase inhibition in the rat. Eur. J. Pharmacol. 80, 155.
Crawley, J.N., Hattox, S.E., Maas, J.W. and Roth, R.H. (1978) 3-methoxy-4-hydroxyphenethy leneglycol increase in plasma after stimulation of the nuclear locus coeruleus.Brain Res. 141, 380.
Del Vecchio, M., Iorio, G., Cocorullo, M., Vacca, L. and Amati, A. (1978) Has SAMe (AdoMet) an antidepressant effect A preliminary trial versus chlorimipramine.Rivista Sperimentale di Freniatria, 102, 344.
Fazio, C., Andreoli, V., Agnoli, A., Casacchia, M., Cerbo, R. and Pinzello, A. (1974) Therapy of schizophrenia and depressive disorders with S-adenosyl-L-methionine. IRCS (Research on: Clinical Pharmacology and Therapeutics; Human Metabolism and Nutrition; Psychiatry and Clinical Psychology; Psychology), 2, 1015.
Fitzgerald, G.A., Watkins, J. and Dolby, C.T. (1981) Regulation of norepinephrine release by peripheral alpha-2 receptor stimulation. Clin. Pharmacol. Ther. 29, 160.
Frishman, W.A. (ed.) (1980) Comparison of Tindolol and Propanolol Treatment, p. 145, Appleton-Century-Crofts, New York.
Goldstein, D.S., McCarty, R., Polinsky, R.J. and Kopin, I.J. (1983) Relationship between plasma norepinephrine and sympathetic neural activity. Hypertension, 5, 552.
Karoum, F. and Neff, N.H. (1982) in Modem Methods in Pharmacology (Spector, S. and Beck, N., Eds.) pp. 39–54, Alan R. Liss, New York.
Kobinger, W. (1978) Central alpha-adrenergic systems as targets for hypotensive drugs. Rev. Physiol. Biochem. Pharmacol. 8, 39.
Kofi-Ekue, J.M., Shanks, R.G. and Walsh, M.J. (1974) Observations on the effects of beta-adrenoceptor blocking drugs on glyceryl trinitrate tachycardia. Br. J. Clin. Pharmacol. 1, 19.
Kufferle, B. and Grinberger, J. (1982) in Typical and Atypical Antidepressants: Clinical Practice (Costa, E. and Racagni, G., Eds.) p. 175, Raven Press, New York.
Linnoila, M., Karoum, F., Calil, H.M., Kopin, I.J. and Potter, W.Z. (1982a) Alteration of norepinephrine metabolism with desipramine and zimelidine in depressed patients. Arch. Gen. Psychiatry 39, 1025.
Linnoila, M., Karoum, F. and Potter, W.Z. (1982b) High correlation of norepinephrine and its major metabolite excretion rates. Arch. Gen. Psychiatry 39, 521.
Linnoila, M., Karoum, F., Rosenthal, N. and Potter, W.Z. (1983) Electroconvulsive treatment and lithium carbonate. Arch. Gen. Psychiatry 40, 677.
Lipinski, J.F., Cohen, B.M., Frankenburg, M.D., Tohen, M., Waternaux, C., Altesman, R., Jones, B. and Harris, P. (1984) Open trial of S-adenosyl-methionine for treatment of depression. Am. J. Psychiatry 141, 448.
Maas, J.W. (ed.) (1983) MHPG: Basic Mechanism and Psychopathology, p. 33. Academic Press, New York.
McDevitt, D.G. (1979) in Advances in Pharmacology and Therapeutics, Proceedings of the Seventh International Congress of Pharmacology. (Tillement, J.P., Ed.) p.77, Pergamon Press, Oxford.
Miccoli, L., Porro, V. and Bertolina, A. (1978) Comparison between the antidepressant activity of S-adenosyl-methionine (SAMe) and that of some tricyclic drugs.Acta Neurologica 33, 243.
Muscettola, G., Galzenati, M. and Balbi, A. (1982) in Typical and Atypical Antidepressants: Clinical Practice, (Costa, E. and Racagni, G., Eds.) p. 151, Raven Press, New York.
Potter, W.Z., Rudorfer, M.V. and Linnoila, M. (in press) New clinical studies support a role of norepinephrine in antidepressant action. Proceedings of the Earl Usdin Memorial Symposium.
Ross, R.J., Scheinin, M., Lesieur, P., Rudorfer, M.V., Hauger, R.L., Siever, L.J., Linnoila, M. and Potter, W.Z. (1985) The effects of clorgyline on noradrenergic function. Psychopharmacology 85, 227.
Ross, R.J., Zavadil, A.P. III, Calil, H.M., Linnoila, M., Kitanaka, I., Blombery, P., Kopin, I.J. and Potter, W.Z (1983) Effects of desmethylimipramine on plasma norepinephrine, pulse and blood pressure. Clin. Pharmacol. Ther. 33, 429.
Rudorfer, M.V., Karoum, F., Ross, R.J., Potter, W.Z. and Linnoila, M. (1985) Differences in lithium effects in depressed and healthy subjects. Clin. Pharmacol. Ther. 37, 66.
Rudorfer, M.V., Ross, R.J., Linnoila, M., Sherer, M.A. and Potter, W.Z. (in press) Exaggerated orthostatic responsivity of plasma norepinephrine in depression. Arch. Gen. Psychiatry.
Salvadorini, F., Mariani, G., Galeone, F. and Saba, P. (1980) Evaluation of S-adenosyl-methionine (SAMe) effectivenes on depression.Cur. Ther. Res. 27, 908.
Spector, S. and Beck N. (eds.) (1982) Modern Methods in Pharmacology, pp. 39–54. Alan R. Liss, New York.
Zavadil, A.P. III, Ross, R.J., Calil, H.M., Linnoila, M., Blombery, P., Jimerson, D.C., Kopin, I.J. and Potter, W.Z. (1984) The effect of desmethylimipramine on the metabolism of norepinephrine. Life Sci. 35, 1061.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 The Humana Press Inc.
About this chapter
Cite this chapter
Sherer, M.A., Rudorfer, M.V., Cantoni, G.L., Golden, R.N., Potter, W.Z. (1986). Noradrenergic and Cardiovascular Effects of Chronic S-Adenyosyl-Methionine in Healthy Volunteers. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_28
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5012-8_28
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9398-9
Online ISBN: 978-1-4612-5012-8
eBook Packages: Springer Book Archive