Regulation of S-Adenosylmethionine and Methylthioadenosine Metabolism in Methylthioadenosine Phosphorylase Deficient Malignant Cells
The synthesis and metabolism of both polyamines and S-adenosyImethionine (Adomet) are important for cell growth regulation. However, our understanding of the regulation of polyamine and Adomet metabol ism in intact mammalian cells is incomplete. 5′-deoxy-5′-methylthioadenosine (abbreviated as MTA or MeSAdo) is the purine end product of the polyamine biosynthetic pathway. Polyamines are organic cations that all dividing cells produce in abundance. Their exact metabolic functions are not known. However, states of increased cellular proliferation, such as cancer, are uniformly associated with accelerated rates of polyamine synthesis (Pegg & McCann, 1982; Heby, et al., 1976.
KeywordsOrnithine Decarboxylase Polyamine Synthesis Methionine Adenosyltransferase Intracellular Polyamine Transmethylation Reaction
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