Regulation of S-Adenosylmethionine and Methylthioadenosine Metabolism in Methylthioadenosine Phosphorylase Deficient Malignant Cells

  • Dennis A. Carson
  • E. Olavi Kajander
  • Carlos J. Carrera
  • Hisashi Yamanaka
  • Taizo Iizasa
  • Masaru Kubota
  • Erik H. Willis
  • John A. Montgomery
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 12)

Abstract

The synthesis and metabolism of both polyamines and S-adenosyImethionine (Adomet) are important for cell growth regulation. However, our understanding of the regulation of polyamine and Adomet metabol ism in intact mammalian cells is incomplete. 5′-deoxy-5′-methylthioadenosine (abbreviated as MTA or MeSAdo) is the purine end product of the polyamine biosynthetic pathway. Polyamines are organic cations that all dividing cells produce in abundance. Their exact metabolic functions are not known. However, states of increased cellular proliferation, such as cancer, are uniformly associated with accelerated rates of polyamine synthesis (Pegg & McCann, 1982; Heby, et al., 1976.

Keywords

Lymphoma Methionine Adenine Nucleoside Hydrolase 

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References

  1. Backlund, P.S. Jr. and Smith, R.A. (1981) J. Biol. Chem. 256, 1533.PubMedGoogle Scholar
  2. Carrera, C.J., Eddy, R.L., Shows, T.B. and Carson, D.A. (1984) Proc. Natl. Acad. Sei. USA 81, 2665.CrossRefGoogle Scholar
  3. Ferro, A.J., Vandenbark, A.A. and MacDonald, M.R. (1981) Biochem, Biophys. Res. Commun., 100, 523.CrossRefGoogle Scholar
  4. Galletti, P., Ollva, A., Manna, C, Della Ragione, F. and Cartenl-Farina, M. (1981) FEES Lstt 126 236.CrossRefGoogle Scholar
  5. German, D.C., Block, C.A. and Kredich, N.M. (1983) J. Biol chem. 258, 7288.Google Scholar
  6. Heby, O., Marton, L.J., Wilson, C.B., and Martinez, H.M. (1975) J. Cel1. Physiol. 86, 511.CrossRefGoogle Scholar
  7. Iizasa, T. and Carson, D.A. (1985) Biochim, Biophys. Acta 844, 280.CrossRefGoogle Scholar
  8. Kamatani, N. and Carson, D.A. (1980) Cancer Res, 40, 4178.PubMedGoogle Scholar
  9. Kamatani, N. and Carson, D.A. (1981) Biochim. Biophys. Acta 675, 344.PubMedGoogle Scholar
  10. Kamatani, N. and Carson, D.A. (1982) Intl. Arch Al1ergy App1. Immunol. 68,84.CrossRefGoogle Scholar
  11. Kamatani, N., Kubota, M., WilIis, E.H., Frincke, L.A. and Carson, D.A. (1984) Adv. Exp, Med, Biol 165B, 83.Google Scholar
  12. Kamatani, N., Nelson-Rees, W.A. and Carson, D.A. (1981) Proc. Natl. Acad. Sci. USA 78, 1219.PubMedCrossRefGoogle Scholar
  13. Kubota, M., Kajander, E.O. and Carson, D.A. (1985) Cancer Res., in press.Google Scholar
  14. Kubota, M., Kamatani, N. and Carson, D.A. (1983) J. Biol. Chem. 258, 7822.Google Scholar
  15. Leonard, N.J. and Tolman, G.L. (1975) Ann. N.Y. Acad. Sci. 255, 43.PubMedCrossRefGoogle Scholar
  16. Mamont, P.S., Joder-Ohlenbusch, A-M, Nussli, M., Grove, J. (1981) Biochem. J.196 411.PubMedGoogle Scholar
  17. Pajula, R.-L., Raina, A. and Eloranta, T. (1979) Eur. J. Biochem. 101, 619.PubMedCrossRefGoogle Scholar
  18. Pegg, A.E. and McCann, P.P. (1982) Am. J. Physiol. 243, C212.PubMedGoogle Scholar
  19. Pegg, A.E. and Williams-Ashman, H.G. (1969) Biochem. J. 115, 241.PubMedGoogle Scholar
  20. Savarese, T.M., Crabtree, G.W. and Parks, R.E., Jr. (1981) Biochem. Pharmacol., 30, 189.PubMedCrossRefGoogle Scholar
  21. Schimke, R.T. and Doyle, D. (1970) Ann, Rev. Biochem. 39, 929.CrossRefGoogle Scholar
  22. Schlenk, F. (1983) Adv. Enzym. 54, 195.Google Scholar
  23. Sufrin, J.R. and Lombardini, J.B. (1982) Mol.Pharmacol 22 752.PubMedGoogle Scholar
  24. Toohey, J.I. (1977) Biochem. Biophys. Res. Com. 78. 1273.PubMedCrossRefGoogle Scholar
  25. White, M.W., Resiol, M.K. and Ferro, A.J. (1983) Biochim. Biophys. Acta 762 405.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Dennis A. Carson
    • 1
  • E. Olavi Kajander
    • 1
  • Carlos J. Carrera
    • 1
  • Hisashi Yamanaka
    • 1
  • Taizo Iizasa
    • 1
  • Masaru Kubota
    • 1
  • Erik H. Willis
    • 1
  • John A. Montgomery
    • 2
  1. 1.Scripps Clinic and Research FoundationLa JollaUSA
  2. 2.Southern Research InstituteBirminghamUSA

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