Abstract
The biochemistry of S-adenosylmethionine (AdoMet) provides several possible strategies for drug design. One focuses on the ability of S-adenosylhomocysteine (AdoHcy) and its analogues to inhibit transmethylation reactions; and involves the design of agents that inhibit transmethylases directly, or inhibit AdoHcy hydrolase causing AdoHcy accumulation, or react intracellularly with homocysteine to form inhibitory analogues of AdoHcy.
Keywords
- Adenosine Deaminase
- Severe Combine Immunodeficiency Disease
- Creatine Synthesis
- Adenosine Deaminase Deficiency
- AdoHcy Hydrolase
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Kredich, N.M., Kotb, M., German, D.C., Bloch, C.A. (1986). Regulation of S-Adenosylmethionine Synthesis in Human Lymphocytes. In: Borchardt, R.T., Creveling, C.R., Ueland, P.M. (eds) Biological Methylation and Drug Design. Experimental Biology and Medicine, vol 12. Humana Press. https://doi.org/10.1007/978-1-4612-5012-8_17
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DOI: https://doi.org/10.1007/978-1-4612-5012-8_17
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