Abstract
Dopamine (DA) metabolism proceeds by two parallel pathways — either through the acid metabolite dihydroxyphenylacetic acid (DOPAC) or through the minor amine 3-methoxytyramine (3-MT) (Westerink, 1979). Both of these metabolites are further processed to form homovanillic acid (HVA). This cascade of metabolites can be used in the following model — DA concentrations reflect synthesis, storage and reuptake of the transmitter while DOPAC concentrations reflect at least two processes, synthesis and reuptake. 3-MT concentrations are an index of the amount of DA released into the synaptic cleft (Carlsson and Lindqvist, 1963; Wood et al., 1982) while HVA concentrations represent the ultimate excretion product of DA metabolism (Roffler-Tarlov et al., 1971). The changes produced concomitantly in all three metabolites and any change in the precursor DA concentrations may accurately reflect the physiological status of dopaminergic neurotransmission.
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McQuade, P.S., Richard, J.W., Thakur, M. (1985). Further Investigations of the Interaction between Phenylethylamine and Dopamine in the Rat Nigrostriatal System. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_20
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DOI: https://doi.org/10.1007/978-1-4612-5010-4_20
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