Anti HTLV-III and Anti T-Cell Antibodies in AIDS and ARC Patients
The number of surface immunoglobulins (SIg)-positive lymphocytes was found to increase when normal lymphocytes were incubated with sera of AIDS or ARC patients. These circulating antilymphocyte antibodies were selectively reactive with 0KT4- but not with 0KT8-staining T-cells. In the present study, AIDS, ARC and control patients were evaluated for antilymphocyte antibodies, anti HTLV-III antibodies and helper/suppressor (h/s) T-cell ratios. In the AIDS group, 23 of 24 patients had circulating HTLV-III antibodies, 24 of 24 showed markedly decreased h/s T-cell ratios and 19 of 21 patients showed marked elevation of anti-lymphocyte antibodies. In contrast, in control patients, none of 14 had HTLV-III antibodies, 13 of 14 had normal h/s T-cell ratios and 3 of 11 showed small increases in antilymphocyte antibodies. In the ARC group, 16 of 16 had circulating anti HTLV-III antibodies. 11 of 15 had decreased h/s T-cell ratios and 6 of 11 showed elevated anti T-cell antibodies. The correlations obtained between these tests and clinical diagnoses indicate their potential usefulness in the detection and monitoring of AIDS and ARC patients.
KeywordsSarcoma Vaccinia Lymphopenia Lymphadenitis
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