Advertisement

Anti HTLV-III and Anti T-Cell Antibodies in AIDS and ARC Patients

  • H. L. Ioachim
  • W. J. Cronin
  • B. H. Dorsett
  • D. Triglia
  • F. C. Jensen
Part of the Experimental Biology and Medicine book series (EBAM, volume 11)

Abstract

The number of surface immunoglobulins (SIg)-positive lymphocytes was found to increase when normal lymphocytes were incubated with sera of AIDS or ARC patients. These circulating antilymphocyte antibodies were selectively reactive with 0KT4- but not with 0KT8-staining T-cells. In the present study, AIDS, ARC and control patients were evaluated for antilymphocyte antibodies, anti HTLV-III antibodies and helper/suppressor (h/s) T-cell ratios. In the AIDS group, 23 of 24 patients had circulating HTLV-III antibodies, 24 of 24 showed markedly decreased h/s T-cell ratios and 19 of 21 patients showed marked elevation of anti-lymphocyte antibodies. In contrast, in control patients, none of 14 had HTLV-III antibodies, 13 of 14 had normal h/s T-cell ratios and 3 of 11 showed small increases in antilymphocyte antibodies. In the ARC group, 16 of 16 had circulating anti HTLV-III antibodies. 11 of 15 had decreased h/s T-cell ratios and 6 of 11 showed elevated anti T-cell antibodies. The correlations obtained between these tests and clinical diagnoses indicate their potential usefulness in the detection and monitoring of AIDS and ARC patients.

Keywords

Herpes Zoster Acquire Immune Deficiency Syndrome Infectious Mononucleosis Male Homosexual Normal Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ioachim, H.L., (1984) Editorial. Acquired Immune Deficiency Disease after Three Years. The Unsolved Riddle. Lab. Invest. 51, 1–6.Google Scholar
  2. 2.
    Ioachim, H.L., Lerner, W.C. & Tapper, M.L. (1983) The Lymphoid Lesions Associated with the acquired immunodeficiency syndrome. Am. J. Surg. Pathol. 7,543.PubMedCrossRefGoogle Scholar
  3. 3.
    Ioachim, H.L., Lerner, W.C. & Tapper, M.L. (1983) Lymphadenopathies in homosexual men: relationships with the acquired immune deficiency syndrome. JAMA 250, 1306.PubMedCrossRefGoogle Scholar
  4. 4.
    Sonnabend J., Witkin, S.S. & Purtilo, D.R. (1983) Acquired immunodeficiency syndrome, opportunistic infections, and malignancies in male homosexuals. JAMA 249, 2370.PubMedCrossRefGoogle Scholar
  5. 5.
    Drew W.L., Miner, R.C., Ziegler, J.L., Gullett, J.H., Abrams, D.I., Conant, M.A., Huang, E.S., Groundwater, J.R., Volberging, P. & Mintz, L. (1982) Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet 1, 125.CrossRefGoogle Scholar
  6. 6.
    McDonald, M.I., Hamilton, J.E. & Durack, D.T. (1983) Hepatitis B surface antigen could harbour the infective agent of AIDS. Lancet 1, 882.CrossRefGoogle Scholar
  7. 7.
    Gallo, R.C., Salahuddin, S.Z., Papovic, M., et al.(1984) Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224, 500.PubMedCrossRefGoogle Scholar
  8. 8.
    Barre-Sinoussi, F., Chermann, J.C., Rey, F. et al.(1983) Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220, 868.PubMedCrossRefGoogle Scholar
  9. 9.
    Sarngadharan, M.G., Popovic, M., Bruch, L. et al.(1984) Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 224, 506.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • H. L. Ioachim
    • 1
    • 2
  • W. J. Cronin
    • 1
    • 2
  • B. H. Dorsett
    • 1
    • 2
  • D. Triglia
    • 1
    • 2
  • F. C. Jensen
    • 1
    • 2
  1. 1.Departments of Pathology of Lenox Hill HospitalCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  2. 2.CytotechSan DiegoUSA

Personalised recommendations