Anti HTLV-III and Anti T-Cell Antibodies in AIDS and ARC Patients
The number of surface immunoglobulins (SIg)-positive lymphocytes was found to increase when normal lymphocytes were incubated with sera of AIDS or ARC patients. These circulating antilymphocyte antibodies were selectively reactive with 0KT4- but not with 0KT8-staining T-cells. In the present study, AIDS, ARC and control patients were evaluated for antilymphocyte antibodies, anti HTLV-III antibodies and helper/suppressor (h/s) T-cell ratios. In the AIDS group, 23 of 24 patients had circulating HTLV-III antibodies, 24 of 24 showed markedly decreased h/s T-cell ratios and 19 of 21 patients showed marked elevation of anti-lymphocyte antibodies. In contrast, in control patients, none of 14 had HTLV-III antibodies, 13 of 14 had normal h/s T-cell ratios and 3 of 11 showed small increases in antilymphocyte antibodies. In the ARC group, 16 of 16 had circulating anti HTLV-III antibodies. 11 of 15 had decreased h/s T-cell ratios and 6 of 11 showed elevated anti T-cell antibodies. The correlations obtained between these tests and clinical diagnoses indicate their potential usefulness in the detection and monitoring of AIDS and ARC patients.
KeywordsHerpes Zoster Acquire Immune Deficiency Syndrome Infectious Mononucleosis Male Homosexual Normal Lymphocyte
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