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Retroviruses and Oncogenes in Rats

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International Symposium: Retroviruses and Human Pathology

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 11))

Abstract

Endogenous retroviral genes are present in all rat species including the feral rats. This virus, termed RaLV, is produced spontaneously in cultures or after treatment of cells in vitro by various chemical or physical agents. The RaLV replicates to low levels in rat cells but does not cause tumors in experimentally inoculated rats. We have isolated an acutely transforming rat sarcoma virus (RaSV) by in vitro cocultivation of RaLV productive cells with that of chemically induced tumor cultures. Unlike the previously isolated murine sarcoma viruses that are hybrids of mouse virus and cellular ras gene, the RaSV contains exclusively rat derived sequences (i.e. rat virus and ras gene). The RaSV transformed nonproducer cells produce a protein of 29,000 daltons which is distinct from all other ras oncogene encoded products in that it is synthesized as a gag-ras fusion product. Thus, the rat-cell-rat-endogenous-virus system that we have established offers a unique model to study the interaction between the endogenous virogenes and cellular genes at various stages of tumor development.

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Author information

Authors and Affiliations

  1. University of Southern California, School of Medicine, 1840 North Soto Street, Los Angeles, Calif., 90032, USA

    S. Rasheed

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  1. S. Rasheed
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Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Robert C. Gallo

  2. Institut Pasteur, Lille, France

    Dominique Stehelin

  3. Istituto di Microbiologia, University of Genova, Genova, Italia

    Oliviero E. Varnier

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© 1985 The Humana Press Inc.

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Rasheed, S. (1985). Retroviruses and Oncogenes in Rats. In: Gallo, R.C., Stehelin, D., Varnier, O.E. (eds) International Symposium: Retroviruses and Human Pathology. Experimental Biology and Medicine, vol 11. Humana Press. https://doi.org/10.1007/978-1-4612-5008-1_14

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  • DOI: https://doi.org/10.1007/978-1-4612-5008-1_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9396-5

  • Online ISBN: 978-1-4612-5008-1

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