Abstract
H-2 congenic C57BL mice were inoculated neonatally with a panel of cloned ecotropic and MCF MuLV isolates. Lymphomas were characterized both for their histology and cell surface marker expression. The results indicate: 1) Synergism exists between ecotropic and MCF viruses in lymphomagenesis. 2) A single ecotropic or dualtropic MCF isolate causes a wide variety of T- and B-cell lymphomas. 3) Within a single mouse strain MuLV induced T-cell lymphomas arise earlier than B-cell lymphomas. 4) The H-2 complex influences lymphoma type. 5) The H-2 complex influences penetration of the thymus by thymotropic MCF virus. 6) These H-2 effects are correlated with H-2 linked differences in the immune responses against both MuLV particles and MuLV-infected cells. A model in which the level of the immune response is one of the main factors determining lymphoma phenotype will be discussed.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Melief, C.J.M., Vlug, A., de Goede, R.E.Y., de Bruyne, C., Barendsen, W. & de Greeve, P. (1980) J. Natl. Cancer Inst. 64, 1179–1189.
Vlug, A., Melief, C.J.M., de Bruyne, C., Schoenmakers, H. & Molenaar, J.L. (1980) J. Natl. Cancer Inst. 64, 1191–1198.
Vlug, A., Schoenmakers, H. & Melief, C.J.M. (1981) J. Immunol. 126, 2355–2360.
Vlug, A., Zijlstra, M., de Goede, R.E.Y., Hesselink, W.G., Schoenmakers, H. & Melief, C.J.M. (1983) Int. J. Cancer 31, 617–626.
Zijlstra, M. de Goede, R.E.Y., Schoenmakers, H., Schinkel, A.H., Hesselink, W.G., Portis, J.L., & Melief, C.J.M. (1983). Virology 125, 47–63.
Zijlstra, M., de Goede, R.E.Y., Schoenmakers, H., Radaszkiewicz, T. & Melief, C.J.M. (1984) Virology, in press.
Klein, J., Juretic, A., Baxevanis, C.W. & Nagy, Z.A. (1981). Nature (London) 291, 455–460.
Debré, P., Boyer, B., Gisselbrecht, S., Bismuth, A. & Levy, J.P. (1980) Eur. J. Immunol. 10, 914–918.
Lonai, P., Katz, E. & Haran-Ghera, N. (1982) Springer Semin. Immunopathol. 4, 373–396.
Meruelo, D. & Bach, R. (1983) Adv. Cancer Res. 40, 107–188.
Lennert, K. (1978) Malignant Lymphomas, Springer, New York
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc.
About this chapter
Cite this chapter
Vasmel, W.L.E., Zijlstra, M., De Goede, R.E.Y., Schoenmakers, H.J., Radaszkiewics, T., Melief, C.J.M. (1985). The Major Histocompatibility Complex (H-2) of the Mouse Influences the Phenotype of Murine Leukemia Virus-Induced Lymphomas. In: Gallo, R.C., Stehelin, D., Varnier, O.E. (eds) International Symposium: Retroviruses and Human Pathology. Experimental Biology and Medicine, vol 11. Humana Press. https://doi.org/10.1007/978-1-4612-5008-1_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5008-1_11
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9396-5
Online ISBN: 978-1-4612-5008-1
eBook Packages: Springer Book Archive