Free Radicals, Dietary Antioxidants and Mechanisms in Cancer Prevention; in Vitro Studies

  • Carmia Borek
Chapter
Part of the Experimental Biology and Medicine, Vol. 10 book series (EBAM, volume 10)

Abstract

It is frequently stated that 90% of the incidence of cancer in a population is due to environmental factors including food consumption and life style (2,32). The definition “environmental” implies non genetic factors though clearly, genetic predisposition plays a role in determining the susceptibility of an individual to becoming a victim of the disease (40).

Keywords

Pyrolysis Half Life Tryptophan Thiol Catalase 

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References

  1. 1.
    Alexander, P. and Lett, J. Comprehensive Biochemistry, pp. 267–356. Florkin, M,.Stots, E. (eds.) Elsevier, Amsterdam, 1968.Google Scholar
  2. 2.
    Ames, B. N. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases, Science 211: 1256–1264, 1983.CrossRefGoogle Scholar
  3. 3.
    Arnott, M. S., Van Eys, J. and Wang, Y. M. Molecular Interactions of Nutrition and Cancer, pp. 1–474, Raven Press, New York, 1982.Google Scholar
  4. 4.
    Barrett, J. C. and Tso, P. O. P. Evidence for the progressive nature of neoplastic transformation In Vitro. Proc. Nat. Acad. Sci. U.S.A. 71: 3761–3765, 1978a.CrossRefGoogle Scholar
  5. 5.
    Benedict, W. F., Wheatly, W. L. and Jones, P. A. Inhibition of Chemically Induced Morphological Transformation and Reversion of Transformed Phenotype by Ascorbic Acid in C3H10T1/2 Cells. Cancer Res. 40 2796–2801, 1980.PubMedGoogle Scholar
  6. 6.
    Berneblum, I. Sequential Aspects of Chemical Carcinogenesis: in. In: Cancer; A Comprehensive Treatise. pp. 451–484, Becker, F. F., (ed.) Plenum Press, New York, 1982.Google Scholar
  7. 7.
    Borek, C. Neoplastic Transformation In Vitro of a Clone of Adult Liver Epithelial Cells into Differentiated Hepatoma-Like Cells under Conditions of Nutritional Stress. Proc. Nat. Acad. Sci. (USA) 69: 956–959, 1972.CrossRefGoogle Scholar
  8. 8.
    Borek, C. X-ray Induced In Vitro Neoplastic Transformation of Human Diploid Cells. Nature 283: 776–778, 1980a.PubMedCrossRefGoogle Scholar
  9. 9.
    Borek, C. Differentiation, Metabolic Activation and Malignant Tranormation in Cultured Liver Cells Exposed to Chemical Carcinogens. In: Advances in Modern Environmental Toxicology. Vol. 1. pp. 297–318. Mishra, N. Dunkel, V. and Mehlman, M. A. (eds) Senate Press, Princeton, New Jersey, 1980b.Google Scholar
  10. 10.
    Borek, C. Radiation Oncogenesis in Cell Culture. Adv. Cancer Res. 37: 159–232, 1982a.PubMedCrossRefGoogle Scholar
  11. 11.
    Borek, C. Vitamins and Micronutrients Modify Carcinogenesis and Tumor Promotion In Vitro. In: Molecular Interrelations of Nutrition and Cancer, PP. 337–350, Arnott, M. S., Van Eys, J. and Wang, Y.M. (eds) Raven Press, New York, 1982b.Google Scholar
  12. 12.
    Borek, C. Permissive and Protective Factors in Malignant Transformation of cells in culture. In: The Biochemical Basis of Chemical Carcinogenesis, pp. 175–188, Greim, H., Juna, R, Kraemer, M., Marquardt, H. and Oesch, F. (eds) Raven Press, New York, 1984a.Google Scholar
  13. 13.
    Borek, C. In Vitro Cell Cultures as Tools in the Study of Free Radicals and Free Radical Modifiers in Carcinogenesis. In: Methods In Enzymology, Volume on Oxygen Radicals in Biological Systems, pp. 465–479. Colowick C. P. Kaplan, N.O. and Packer, L. (eds) Academic Press, New York, 1984b.Google Scholar
  14. Borek, C. The Induction and Control of Radiogenic Transformation In Vitro: Cellular and Molecular Mechanisms. J. Pharmach. and Therap. 1985, In Press.Google Scholar
  15. 15.
    Borek, C. and Andrews, A. Oncogenic Transformation of Normal, XP and Bloom Syndrome Cells by X-Rays and Ultraviolet Irradiation. In: Human Carcinogenesis, pp. 519–541, Harris, C. C. and Antrup, H. (eds) Academic Press, New York, 1983.Google Scholar
  16. 16.
    Borek, C. and Biaglow, J. E. Factors Controlling Cellular Peroxide Breakdown: Relevance to Selenium Protection against Radiation and Chemically Induced Carcinogenesis. Proc. Am. Ass. Cancer Res. 25: 125 (abstract), 1984.Google Scholar
  17. 17.
    Borek, C. and Cleaver, J.E. Protease Inhibitors Neither Damage DNA nor Interfered with DNA in Human Cells. Mutat. Res. 82: 373–380, 1981.PubMedCrossRefGoogle Scholar
  18. 18.
    Borek, C., Cleaver, J. E. and Fujiki, H. Critical Biochemical and Regulatory Events in Malignant Transformation and Promotion In Vitro. In: Cellular Interaction by Environmental Tumor Promoters and Relevance to Human Cancer, Fujiki, H. et al. (ed) Japan Scientific Societies, Tokyo, 1984a, in press.Google Scholar
  19. 19.
    Borek, C. and Guernsey, D. Membrane Associated Ion Transport Enzymes in Normal and Oncogenically Transformed Fibroblasts and Epithelial Cells. Studia Biophysica 81 (1): 53–54, 1981.Google Scholar
  20. 20.
    Borek, C., Guernsey, D. L., Ong, A. and Edelman, I. S. Critical Role Played by Thyroid Hormone in Induction of Neoplastic Transformation by Chemical Carcinogens in Tissue Culture. Proc. Natn. Acad. Sci. U.S.A 80: 5749–5752, 1983a.CrossRefGoogle Scholar
  21. 21.
    Borek, C., Higashino, S, and Loewenstein, W. R. Intercellular Communication and Tissue Growth-IV. Conductance of Membrane Junctions of Normal and Cancerous Cells in Culture. J. Memb. Biol. 1: 274–293, 1969.CrossRefGoogle Scholar
  22. 22.
    Borek, C., Miller, R.C., Geard, C. R., Guernsey, D. L. and Smith, J. E. In Vitro Modulation of Oncogenesis and Differentiation by Retinoids and Tumor Promoters. In: Carcinogenesis. Vol. 7, pp. 277–284, Hecker, E. (ed) Raven Press, New York, 1982.Google Scholar
  23. 23.
    Borek, C., Miller, R., Pain, C. and Troll, W. Conditions for Inhibiting and Enhancing Effects of the Protease Inhibitor Antipain on X-Ray-Induced Neoplastic Transformation in Hamster and Mouse Cells. Proc. Natn. Acad. Sci. U.S.A. 76: 1800–1803, 1979.CrossRefGoogle Scholar
  24. 24.
    Borek, C. and Ong, A. The Interaction of Ionizing radiation and Food Pyrolysis Products in Producing Oncogenic Transformation In Vitro. Cancer Lett. 12: 61–66, 1981.PubMedCrossRefGoogle Scholar
  25. 25.
    Borek, C., Ong, A., Donohue, L. and Biaglow, J. E. Selenium Protects against In Vitro Radiation and Chemically Induced Transformation by Controlling Peroxide Breakdown. Proc. Natn. Acad. Sci. U.S.A., 1984C, in press.Google Scholar
  26. 26.
    Borek, C. and Sachs, L. In Vitro Cell Transformation by X-Irradiation Nature 210: 276–278, 1966a.PubMedCrossRefGoogle Scholar
  27. 27.
    Borek, C. and Sachs, L. Cell Susceptibility to Transformation by X-Irradiation and Fixation of the Transformed State. Proc. Natn. Acad. Sci. U.S.A. 57: 1522–1527, 1967.CrossRefGoogle Scholar
  28. 28.
    Borek, C. and Sachs, L. The Numbers of Cell Generations required to fix the transformed state in X-ray Induced Transformation. Proc. Natn. Acad. Sci. U.S.A. 59: 83–85.Google Scholar
  29. 29.
    Borek, C. and Troll, W. Modifiers of Free Radicals Inhibit In Vitro the Oncogenic Actions of X-Rays, Bleomycin, and the Tumor Promoter 12-0-tetradecanoylphorbol 13-Acetate. Proc. Natn. Acad. Sci. U.S.A. 80: 5749–5752.Google Scholar
  30. 30.
    Boutwell, R. K. Retinoids and Prostaglandin Synthesis Inhibitors as Protective Agents against Chemical Carcinogenesis and Tumor Promotion. In: Radioprotectors and Anticarcinogens, Nygaard, O. K. and Simic, M.G. (eds) A. P. New York, 557–566, 1983.Google Scholar
  31. 31.
    Cooper, G. M. Cellular Transforming Genes. Science 218: 801–806, 1982.CrossRefGoogle Scholar
  32. 32.
    Doll, R. and Peto, R. The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today. J. Natn. Cancer Inst. 66: 1191–1308, 1981.Google Scholar
  33. 33.
    Fridovich, I. The Biology of Oxygen Radicals. Science 201: 875–880, 1978.PubMedCrossRefGoogle Scholar
  34. 34.
    Fujiki, H., Mori, M., Nakayasu, M., Terada, M. and Sugimura, T. A Possible Naturally Occurring Tumor Promoter, Teleocidin B from Streptomyces. Biochem. Biophys. Res. Commun. 90: 976–983, 1979.PubMedCrossRefGoogle Scholar
  35. 35.
    Geard, C. R., Freeman, M. R., Miller, R. C. and Borek, C. Antipain and Radiation Effects on Oncogenic Transformation and Sister Chromatid Exchanges in Syrian Hamster Embryo and Mouse C3H10T1/2 cells. Carcinogenesis 2: 1229–1235.Google Scholar
  36. 36.
    Goldstein, B. D., Witz, G., Amoruso, M., Stone, D.S. and Troll, W. Stimulation of Human Polymorphonuclear Leukocyte Superoxide Anion Radial Production by Tumor Promoters. Cancer Lett. 11: 257–262, 1981.PubMedCrossRefGoogle Scholar
  37. 37.
    Guernsey, D.L. Borek, C. and Edelman, I. S. Crucial Role of Thyroid Hormone in X-Ray Induced Transformation in Cell Culture. Proc. Natn. Acad. Sci. U.S.A. 78: 5708–5711, 1981.CrossRefGoogle Scholar
  38. 38.
    Guernsey, D. L., Ong, A. and Borek, C. Modulation of X-Ray Induced Neoplastic Transformation In Vitro by Thyroid Hormone. Nature 288: 591–592, 1980.PubMedCrossRefGoogle Scholar
  39. 39.
    Harisiadis, L., Miller, R. C., Hall, E. J. and Borek, C. A Vitamin A Analogue Inhibits Radiation-Induced Oncogenic Transformation. Nature 274: 486–487, 1978.PubMedCrossRefGoogle Scholar
  40. 40.
    Harnden, D. G. The Nature of Inherited Susceptibility to Cancer. Carcinogenesis 5: 1535–1537, 1984.PubMedCrossRefGoogle Scholar
  41. 41.
    Kennedy, A. R., Murphy, G. and Little, J. B. Effect of Time and Duration of Exposure to 12-0-Tetradecanoylphorbol-13-Acetate on X-Ray Transformation of C3H 10T1/2 cells. Cancer Res. 40: 1915–1920, 1980b.PubMedGoogle Scholar
  42. 42.
    Lotan, R. Effects of Vitamin A and its Analogs (Retinoids) on Normal and Neoplastic Cells. Biochem. Biophys. Acta. 605: 33–91, 1980.PubMedGoogle Scholar
  43. 43.
    Medina, D. Selenium Mediated Inhibition of Mouse Mammary Tumorgenesis, Cancer Lett. 8: 281–245, 1980.CrossRefGoogle Scholar
  44. 44.
    Miller, R. C., Geard, C. R., Osmak, R. S., Rutledge Freeman, M., Ong, A., Mason, H., Napholtz, A., Perez, N., Harisiadis, L. and Borek, C. Modified of Sister Chromatid Exhchanges and radiation-induced transformation in rodent Cells by the Tumor Promoter 12-0-Tetradecanoyl-Phorbol-13-Acetate and two retinoids, Cancer Res. 41: 655–659, 1981.PubMedGoogle Scholar
  45. 45.
    Pryor, W. A. The Role of Free Radical Reactions in Biological Systems. In: Free Radicals in Biology. Vol. 1, pp. 1–49, Pryor, W. A. (ed) Academic Press, New York, 1976.Google Scholar
  46. 46.
    Radioprotectors and Anticarcinogens, Nygaard, O.F. and Simic, M.G. (eds), Academic Press, New York, 1983.Google Scholar
  47. 47.
    Slaga, T. G., Klein-Szanto, A. J. P., Triplett, L. L. and Yotti, P. C. Skin Tumor Promoting Activity of Benzoyl Peroxide, Science (Wash.) 213: 1023–1024, 1981.CrossRefGoogle Scholar
  48. 48.
    Sporn, M. B., Dunlop, N. M., Newton, D. L. and Henderson, W. R. Relationships between structure and activity of retinoids. Nature 263: 110–113, 1976.PubMedCrossRefGoogle Scholar
  49. 49.
    Sugimura, T. Tumor Initiators and Promoters Associated with Ordinary Foods. In: Molecular Interrelations of Nutrition and Cancer, pp. 3–24, Arnott, M.S, Van Eys, J. and Wang, Y. M. (eds) Raven Press, New York, 1982.Google Scholar
  50. 50.
    Troll, W., Witz, Gisela, Goldstein, B., Stone, D. and Sugimura, T. The Role of Free Oxygen Radicals in Tumor Promotion and Carcinogenesis. Carcinogenesis, Vol. 7: pp. 593–597, Raven Press, New York, 1982.Google Scholar
  51. 51.
    Wattenberg, L.W., Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Antioxidants and Ethoxygnin J. Nat. Cancer Inst. 48: 1425–1430, 1972.PubMedGoogle Scholar
  52. 52.
    Wigler, M. and Weinstein, I.B. Tumor Promoter Induces Plasminogen Activator. Nature 259: 232–233, 1976.PubMedCrossRefGoogle Scholar
  53. 53.
    Zimmerman, R. and Cerutti, P. Active Oxygen Acts as a Promoter of Transformation in Mouse Embryo C3H 10T1/2C18 Fibroblasts. Proc. Natn. Acad. Sci. U.S.A. 81: 2085–2087, 1984.CrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • Carmia Borek
    • 1
  1. 1.Departments of Pathology and RadiologyColumbia University, College of Physicians & SurgeonsNew YorkUSA

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