Abstract
In laboratory studies retinoids have potent effects as inhibitors of carcinogenesis at the promotion phase and are stimulators of differentiation and maturation and growth inhibitors of established tumor cells in vitro (9,14). Additionally, epidemiological data in general supports the contention that vitamin A is a natural inhibitor (anti-promoter) of many human cancers (6,7). Early data suggested that vitamin A was necessary for normal epithelial cell maturation and limited studies over a decade ago suggested that retinoic acid was growth inhibitory to human skin cancers (2). These observations have prompted us to study retinoids in the prevention and treatment of human cancer and the results from these studies are summarized here.
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Meyskens, F.L. (1986). Experience with Retinoids as Prevention and Treatment for Human Cancers. In: Meyskens, F.L., Prasad, K.N. (eds) Vitamins and Cancer. Experimental Biology and Medicine, Vol. 10, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-5006-7_30
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DOI: https://doi.org/10.1007/978-1-4612-5006-7_30
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